Clinical Research Directory

Inclusion Criteria: * Mechanically ventilated adult patients (\>18 years old) admitted to ICU with an expected ICU dependency (alive and need for mechanical ventilation * Vasopressor therapy, or mechanical circulatory support) at the point of screening of an additional 3 days, as estimated by the treating physician. Exclusion Criteria: * Patients who are moribund (expected death within 48 hours) * Expected to have life-sustaining treatments withdrawn in the next 3 days * Those with a contraindication to enteral nutrition (EN) * Already on parenteral nutrition (PN) * Those with acute fulminant hepatitis or severe chronic liver disease (Child's class C) * Patients on extracorporeal membrane oxygenation or carbon dioxide removal\* Patients with organ transplantation * Those with a broncho-pleural fistula * Patients with documented allergies to any of the study nutrients or its excipients will be excluded. * Patients requiring continuous renal replacement therapy or extracorporeal membrane oxygenation are excluded due to inability to accurately measure protein turnover.