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Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation
Sponsor: Centre Oscar Lambret
Summary
The aim of the study is to perform a French multicenter prospective interventional study in order to assess the feasibility and safety of ovarian hyperstimulation for oocyte / embryo cryopreservation in young women with breast cancer. The oncologic and reproductive benefit / risk ratio will be investigated in the oncology and reproductive area.
Official title: Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation (CHACRY-1501)
Key Details
Gender
FEMALE
Age Range
18 Years - 38 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2016-12
Completion Date
2034-11
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Interventions
Controlled ovarian hyperstimulation (COH)
After information and consent, patients are addressed to a reproductive medicine center. The COH will be performed according to a standardized protocol between surgery and the start of adjuvant chemotherapy. Follicular growth will be achieved with an antagonist protocol and by using high dose recombinant FSH (r-FSH). The triggering of the final follicular and oocyte maturation will be obtained by a GnRH (Gonadotropin Releasing Hormone) agonist injection in order to minimize the risk of ovarian hyper-stimulation.
Oocyte/embryo freezing
Egg or embryo freezing will be performed according to a standardized protocol: slow-freezing process for embryo; vitrification technique for oocytes. Cryopreserved oocytes and embryos will be stored in the biological bank of each reproductive medicine center (min. 10 years).
Locations (28)
Hôpital Jean Verdier
Bondy, France
Centre Aliénor d'Aquitaine, Hôpital Pellegrin
Bordeaux, France
CHU de Caen
Caen, France
Centre François Baclesse
Caen, France
Hôpital Antoine Béclère
Clamart, France
Centre Georges François LECLERC
Dijon, France
CHU de Dijon
Dijon, France
CHU REUNION site SUD
La Réunion, France
Centre Oscar Lambret
Lille, France
CHRU Hôpital Jeanne de Flandres
Lille, France
CHU Limoges
Limoges, France
CHU Lyon
Lyon, France
Centre Léon Bérard
Lyon, France
CHU La Conception
Marseille, France
Institut Paoli Calmette
Marseille, France
CHRU Montpellier
Montpellier, France
ICM - Val d'Aurelle
Montpellier, France
CHRU de Nancy
Nancy, France
Institut Curie
Paris, France
Hôpital Cochin
Paris, France
Hôpital TENON
Paris, France
CHU Rouen
Rouen, France
Centre Henri Becquerel
Rouen, France
Institut Curie
Saint-Cloud, France
Hôpital Universitaire de Strasbourg
Strasbourg, France
Oncopole-CHU Toulouse
Toulouse, France
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France
Institut Gustave Roussy
Villejuif, France