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Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
Adult patients who require multiple dental restorations will be included in this study. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. We will determine global alterations in DNA methylation and DNA hydroxymethylation levels using UPLC-MS/MS.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2018-05-02
Completion Date
2025-11
Last Updated
2024-07-03
Healthy Volunteers
Yes
Conditions
Interventions
Dental restoration
Damaged teeth will be restored
Locations (1)
BIOMAT, Department of Oral Health Sciences
Leuven, Belgium