Clinical Research Directory

Inclusion Criteria: Term ≥ 36 weeks of gestation * and (2) : * a blood pH \< 7 with base deficit \> 12 mmol/l (at birth or within 60 minutes of age) * or a blood pH between 7,01 and 7,15, with additionnal criteria: * a history of acute perinatal event (e.g : abnormal fetal cardiac rate, cord prolapse, uterine rupture, maternal hemorrhage) * and a 5 minutes Apgar score ≤ 5, or a continued need for resuscitation, including endotracheal or mask ventilation at 5 min after birth. * signs of encephalopathy within 12 hours of age (Sarnat and Sarnat classification, score ≥ 2) * ± abnormal electroencephalogram or aEEG within 12 hours of age * therapeutic hypothermia. * no maternal infection with VIH, HTLV 1 or 2, Hepatitis B or C virus. * maternal negative serology for syphilis * written parental consent Exclusion Criteria: * presence of known chromosomal anomaly. * presence of major congenital anomalies. severe intrauterine growth restriction (weight \<1800g) * infants in extremis for whom no additional intensive therapy will be offered by attending neonatologist.