Clinical Research Directory

Inclusion Criteria: For all patients groups: * Age ≥ 18, * Social security. " Hypercortisolism " group: * 18 \< BMI \< 40 kg/m2, * Cushing's syndrome in front of : * impaired 1 mg dexamethasone test (08:00 A.M. cortisol \> 50 nmol/L) * qualitative and quantitative disrupted circadian rhythm of cortisol with increased plasma concentrations * free urinary cortisol upper normal range (90 µg/24H), * Hypercortisolism that can be treated with surgery (adrenal adenoma treated with adrenalectomy or Cushing disease treated with pituitary surgery). " Obese " group: * Obese patients: 30 \< BMI \< 40 kg/m2, * Normal HPA axis function: * 08:00 A.M. cortisol \> 250 nmol/L and peak above 550 nmol/L after 1 mg SST, * Normal 24H free urinary cortisol and dexamethasone test. " Control " group: * Lean or overweight patients (18 \< BMI \< 30 kg/m2), * Non cortisol secreting pituitary or adrenal tumor, * Patient in whom a biological evaluation of the HPA axis is recommended. " Hydrocortisone " group: * Lean or overweight patients (18 \< BMI \< 30 kg/m2), * Primary or secondary adrenal insufficiency, * With a need for hydrocortisone supplementation. Exclusion Criteria: * Patients with eating disorders, major depressive disorders or psychiatric disorders other than Cushing's syndrome, * Cannabis consumption, alcoholism or drug addiction, * Active smoking, * cortisone treatment other than hydrocortisone, * Pregnancy or feeding, * Surgery for obesity, * Incapability, * Pathology that is life-threatening in the short term, * Any situation that interfere with study or is risked for patient.