Clinical Research Directory
Browse clinical research sites, groups, and studies.
Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)
Sponsor: AbbVie
Summary
A Phase 2, open-label, dose escalation study to evaluate the safety and efficacy of venetoclax in combination with carfilzomib-dexamethasone (Kd) in participants with relapsed or refractory MM and have received 1 to 3 prior lines of therapy. Part 4 of this study is currently enrolling.
Official title: A Phase 2, Open-Label, Multi-Center Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2017-01-19
Completion Date
2027-06
Last Updated
2025-08-05
Healthy Volunteers
No
Conditions
Interventions
Carfilzomib
Carfilzomib lyophilized administered intravenously as a 10 to 30 minute infusion in Cycles 1 and beyond within 30 minutes to 4 hours after dexamethasone dosing. Dose level 1 (K1) Cycle 1: 20 mg/m2 on Days 1 and 2, 27 mg/m2 on Days 8, 9, 15, and 16; Cycles 2 - 12: 27 mg/m2 on Days 1, 2, 8, 9, 15, and 16; Cycles 13 - 18: 27 mg/m2 on Days 1, 2, 15, and 16; Cycles 19 and beyond, for participants that have not previously transitioned to monotherapy: 27 mg/m2 on Days 1, 2, 15, and 16. Dose Level K2: Cycle 1: 20 mg/m2 on Day 1; 70 mg/m2 on Days 8 and 15 Cycles 2 - onward: 70 mg/m2 on Days 1, 8, and 15. Dose Level K3: Cycle 1: 20 mg/m2 on Days 1 and 2; 56 mg/m2 on Days 8, 9, 15, and 16. Cycles 2 - onward: 56 mg/m2 on Days 1, 2, 8, 9, 15, and 16.
Venetoclax
Venetoclax tablet administered orally once daily during Cycles 1 - onward. Venetoclax dose level 1 (Ven1) 400 mg once daily, Ven2 800 mg once daily.
Dexamethasone
Dexamethasone tablet administered orally during Cycles 1 - onward. Dexamethasone dose level 1 (Dex1) 40 mg once weekly, Dex2 40 mg once weekly, Dex3 20 mg twice weekly.
Locations (32)
University of Alabama at Birmingham - Main /ID# 151405
Birmingham, Alabama, United States
University of Arkansas for Medical Sciences /ID# 151399
Little Rock, Arkansas, United States
Memorial Healthcare System /ID# 224862
Hollywood, Florida, United States
Winship Cancer Institute of Emory University /ID# 161710
Atlanta, Georgia, United States
The University of Chicago Medical Center /ID# 151395
Chicago, Illinois, United States
Indiana Blood & Marrow Transpl /ID# 218862
Indianapolis, Indiana, United States
Duplicate_University of Kentucky Chandler Medical Center /ID# 151407
Lexington, Kentucky, United States
Central Maine Medical Center /ID# 218856
Lewiston, Maine, United States
Duplicate_University of Maryland School of Medicine /ID# 159721
Baltimore, Maryland, United States
Oncology Hematology Associates (OHA) - Springfield /ID# 218855
Springfield, Missouri, United States
Washington University-School of Medicine /ID# 222651
St Louis, Missouri, United States
Duke Cancer Center /ID# 162062
Durham, North Carolina, United States
University of Pennsylvania /ID# 151768
Philadelphia, Pennsylvania, United States
University of Texas Southwestern Medical Center /ID# 218336
Dallas, Texas, United States
Baylor Scott & White Medical Center- Temple /ID# 218252
Temple, Texas, United States
University of Utah /ID# 151397
Salt Lake City, Utah, United States
Duplicate_VA Puget Sound Healthcare Syst /ID# 155369
Seattle, Washington, United States
Aurora Health Care, Aurora Cancer Center /ID# 209612
Wauwatosa, Wisconsin, United States
Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 222200
East Albury, New South Wales, Australia
Calvary Mater Newcastle /ID# 218739
Waratah, New South Wales, Australia
Flinders Medical Centre /ID# 221345
Bedford Park, South Australia, Australia
Royal Hobart Hospital /ID# 217546
Hobart, Tasmania, Australia
Debreceni Egyetem-Klinikai Kozpont /ID# 217624
Debrecen, Hajdú-Bihar, Hungary
Semmelweis Egyetem /ID# 217626
Budapest, Hungary
Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 217625
Budapest, Hungary
Szegedi Tudományegyetem /ID# 219172
Szeged, Hungary
Auxilio Mutuo Cancer Center /ID# 157853
San Juan, Puerto Rico
VA Caribbean Healthcare System /ID# 157854
San Juan, Puerto Rico
Hospital Universitario Germans Trias i Pujol /ID# 218006
Badalona, Barcelona, Spain
Hospital Clinic de Barcelona /ID# 218007
Barcelona, Spain
Hospital General Universitario Gregorio Maranon /ID# 218005
Madrid, Spain
Hospital Universitario Ramon y Cajal /ID# 220925
Madrid, Spain