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Bariatric Surgery and Pharmacokinetics of Amlodipine
Sponsor: Norwegian University of Science and Technology
Summary
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study we investigate the pharmacokinetic effects of bariatric surgery on amlodipine.
Official title: Bariatric Surgery and Pharmacokinetics Amlodipine: BAR-MEDS Amlodipine
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
12
Start Date
2016-11
Completion Date
2026-05
Last Updated
2025-06-06
Healthy Volunteers
No
Conditions
Interventions
Amlodipine
Patients are tested for their normal prescription amlodipine medication
Locations (1)
St. Olavs University Hospital
Trondheim, Norway