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RECRUITING
NCT02916810
NA

Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment

Sponsor: The University of Texas Health Science Center, Houston

View on ClinicalTrials.gov

Summary

The purpose of the study is to test the hypothesis that functionally navigated repetitive TMS stimulations to the prefrontal cortex (PFC) modulate aberrant cortical electrical activities at PFC circuitry. The TMS location of the PFC site will be individually localized by the symptom-related functional connectivity between PFC and symptom related areas (such as the auditory and language processing cortex). The investigators predict that such modulation will correct abnormal activities in patients with schizophrenia, reduce symptoms, especially auditory hallucination, and improve working memory/sustained attention performance.

Key Details

Gender

All

Age Range

18 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

140

Start Date

2025-02-01

Completion Date

2029-07-01

Last Updated

2025-07-28

Healthy Volunteers

No

Interventions

DEVICE

Active rTMS stimulation

Participants will receive two rTMS sessions in each treatment visit for up to 22 visits within about 6 weeks. There is a 30-minute rest between the two rTMS sessions.

DEVICE

Sham rTMS stimulation

Participants will receive two sham rTMS sessions in each treatment visit for up to 22 visits within about 6 weeks. There is a 30-minute rest between the two sham rTMS sessions.

Locations (1)

The University of Texas Health Science Center at Houston

Houston, Texas, United States