Clinical Research Directory

Inclusion Criteria: * Resectable adenocarcinoma of the pancreatic head * T1-3, Nx, M0 (UICC 7th version, 2010) * Cytologic or histologic confirmation of adenocarcinoma * Age \> 18 year and considered fit for major surgery * Written informed consent * Considered able to receive the study specific chemotherapy Exclusion Criteria: * Co-morbidity precluding pancreaticoduodenectomy * Chronic neuropathy ≥ grade 2 * WHO performance score \> 2 • Granulocyte count \< 1500 per cubic millimetre * Platelet count \< 100 000 per cubic millimeter * Serum creatinine \> 1.5 UNL (upper limit normal range) * Albumin \< 2,5 g/dl * Female patients in child bearing age not using adequate contraception, pregnant or lactating women • Mental or organic disorders which could interfere with informed consent or treatments * Other malignancy within the past 5 years, except non-melanomatous skin or non-invasive cervical cancer * Percutaneous tumor biopsy * Any reason why, in the opinion of the investigator, the patient should not participate * Pregnancy * Breastfeeding