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Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis
Sponsor: Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Summary
The purpose of this study is to determine the efficacy of high-dose corticosteroid pulses added to conventional oral corticosteroid course for moderate flares of ulcerative colitis.
Official title: Efficacy of High-dose Corticosteroid Pulses Added to Conventional Oral Corticosteroid Course for Moderate Flares of Ulcerative Colitis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2018-10-11
Completion Date
2022-11-07
Last Updated
2026-06-02
Healthy Volunteers
No
Conditions
Interventions
Methylprednisolone
Intravenous bolus of methylprednisolone 0.5g/day for 3 consecutive days followed by a decreasing conventional course of oral prednisone (week1; 60mg/d, w2; 50mg/d, w3;40mg/d, w4; 30mg/d, w5; 20mg/d, w6; 15mg/d, w7; 10mg/d, w8; 5 mg/d, w9; 0mg/d)
Prednisone
Conventional course of oral prednisone (week1; 60mg/d, w2; 50mg/d, w3;40mg/d, w4; 30mg/d, w5; 20mg/d, w6; 15mg/d, w7; 10mg/d, w8; 5 mg/d, w9; 0mg/d)
Locations (29)
Complejo Hospitalario Universitario Santiago de Compostela
Santiago de Compostela, A Coruña, Spain
Hospital Germans Trias i Pujol
Badalona, Barcelona, Spain
Althaia, xarxa assistencial universitaria de Manresa
Manresa, Barcelona, Spain
Consorci Corporació Sanitària Parc Taulí
Sabadell, Barcelona, Spain
Hospital Moisès Broggi
Sant Joan Despí, Barcelona, Spain
Consorci Hospitalari de Terrassa
Terrassa, Barcelona, Spain
Hospital de Galdakao
Galdakao, Bilbao, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain
hospital Puerta de Hierro-Majadahonda
Majadahonda, Madrid, Spain
Hospital Universitario de Ourense
Ourense, Ourense, Spain
Hospital Álvaro Cunqueiro
Vigo, Pontevedra, Spain
Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, Spain
Hospital Universitario Cruces
Barakaldo, Vizcaya, Spain
Hospital General Universitario de Alicante
Alicante, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital del Mar
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital Universitari Dr. Josep Trueta
Girona, Spain
Hospital De La Princesa
Madrid, Spain
Hospital Gregorio Marañon
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital 12 de Octubre
Madrid, Spain
Hospital Universitario Ramon y Cajal
Madrid, Spain
Mútua de Terrassa
Terrassa, Spain
Hospital Clínico de Valencia
Valencia, Spain
Hospital Universitario General de Valencia
Valencia, Spain
Hospital de Manises
Valencia, Spain
Hospital Universitari La Fe
Valencia, Spain
Hospital Universitario Río Hortega
Valladolid, Spain