Clinical Research Directory

Inclusion Criteria: * Subject must be at least 21years of age and at least the minimum Age of Majority according to applicable state law. * Subject is a suitable surgical candidate, i.e. is able to undergo appropriate anesthesia and endoscopic procedure or laparoscopic surgery. * Appropriate indications for and documentation of disease process requiring surgery. (Documented gastroesophageal reflux disease by accepted endoscopic or ambulatory reflux monitoring criteria, or have a hiatal hernia that meets accepted criteria for repair (e.g. large paraesophageal hernia with chest pain)). * Subject is willing and able to cooperate with follow-up examinations * Subject has been informed of the study procedures and treatment and has signed an informed consent for the study. Exclusion Criteria: * Suspected or confirmed esophageal or gastric cancer. * Cannot understand trial requirements or is unable to comply with follow-up schedule * Pregnant or nursing, or plans to become pregnant during the course of the study * Medical illness (i.e. congestive heart failure) that may cause the subject to be non-compliant with or able to meet the protocol requirements or is associated with limited life expectancy (i.e. less than 3 years) * Diagnosed psychiatric disorder (e.g. bipolar, schizophrenia, etc.), subjects that exhibit depression that are on appropriate medication(s) are allowable.