Clinical Research Directory

* Aged over 18 years * Presenting with severe mitral valve stenosis or regurgitation regardless of etiology (primary mitral regurgitation, secondary mitral regurgitation, deterioration of mitral valve repair or bioprosthesis, mitral annular calcification) * Symptomatic (NYHA functional class II-IV) despite optimized medical therapy * Judged not eligible for surgical treatment according to a specialized multidisciplinary meeting called "heart team" comprising at least one cardiothoracic surgeon, one interventional cardiologist, one echocardiographer, one clinical cardiologist and one anaesthesiologist. * Having received information about the study and not expressing opposition to the use of their data * Patient not included in a clinical trial Exclusion Criteria: * Asymptomatic patients * Absence of severe mitral regurgitation or stenosis * Patient judged eligible for surgical treatment according to a specialized multidisciplinary meeting called "heart team" comprising at least one cardiothoracic surgeon, one interventional cardiologist, one echocardiographer, one clinical cardiologist and one anaesthesiologist. * Pregnant or breastfeeding women * Having not received information about the study or having expressed opposition to the use of their data