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The Influence of Helicobacter Pylori Eradication on Gastric Pathology: a Long-term, Prospective Cohort Study
Sponsor: Shandong University
Summary
Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer. By causing progressive damage to the stomach and may eventually result in gastric atrophy, H. pylori infection has been demonstrated to be responsible for more than 95% of gastric malignancies
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2016-10
Completion Date
2031-10
Last Updated
2016-10-14
Healthy Volunteers
No
Conditions
Interventions
biopsy
patients enrolled in the study will receive gastroscopy and biopsies in order to evaluate status of pathology.
H. pylori eradication
H. pylori eradication therapy comprising esomeprazole, amoxicillin,clarithromycin and colloidal bismuth pectin. If failed in eradicating H. pylori, a culture based antimicrobial susceptibility test will be used to guide H. pylori eradication.
Locations (1)
Department of Gastroenterology, Qilu Hospital, Shandong University
Jinan, Shandong, China