Clinical Research Directory

Inclusion Criteria: * Patients fulfilling the following criteria will be eligible for inclusion in the study: * PMF, post-ET MF, or post-PV MF. * Int-2 or high-risk disease as determined by the DIPSS. * Age ≥55 at the time of DIPSS assessment. * For the alloHCT arm: * Donors must be a 6/6 HLA-matched related donors, defined by Class I (HLA-A and -B) intermediate resolution or high resolution DNA-based typing and Class II (HLA-DRBI) at high resolution DNA-based typing (but not monozygotic twins) OR an 8/8 HLA-A, -B, -C, and -DRB1 at high resolution DNA-based typing matched unrelated donor identified through the National Marrow Donor Program (NMDP)/Be The Match. Donors must meet institutional or NMDP/Be The Match selection criteria; there is no age restriction for sibling donors. * Both peripheral blood stem cells and bone marrow grafts are allowed. * All conditioning regimen intensities are allowed. * All GVHD prophylaxis regimens are allowed. * Haploidentical donors are allowed in the Haploidentical Donor Study Exclusion Criteria: * Patients with the following criteria will be ineligible for entry into the study: * AlloHCT using umbilical cord blood unit(s) or HLA-mismatched adult donors (\< 6/6 HLA alleles for related and \< 8/8 HLA alleles for unrelated). * Overlap syndromes.