Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study Evaluating Venetoclax in Combination With Azacitidine in Participants With Treatment-Naïve Higher-Risk Myelodysplastic Syndromes (MDS)
Sponsor: AbbVie
Summary
This is a Phase 1b, open-label, non-randomized, multicenter, dose-finding study evaluating venetoclax in combination with azacitidine in participants with treatment-naïve higher-risk MDS comprising a dose-escalation portion and a safety expansion portion.
Official title: A Phase 1b Dose Escalation Study Evaluating the Safety and Pharmacokinetics of Venetoclax in Combination With Azacitidine in Subjects With Treatment-Naïve Higher-Risk Myelodysplastic Syndromes (MDS)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
129
Start Date
2017-01-12
Completion Date
2027-01
Last Updated
2025-08-05
Healthy Volunteers
No
Conditions
Interventions
Azacitidine
Powder for injection; taken subcutaneously (SC) or intravenous (IV); Administered on Days 1-7 of 28 days cycle or Days 1-5 of Week 1 \& Days 1-2 of Week 2 of 28 day cycle.
Venetoclax
Oral; Tablet
Locations (37)
Duplicate_University of Arizona Cancer Center - North Campus /ID# 154155
Tucson, Arizona, United States
The University of Chicago Medical Center /ID# 153673
Chicago, Illinois, United States
University of Maryland, Baltimore /ID# 153669
Baltimore, Maryland, United States
Tufts Medical Center /ID# 153672
Boston, Massachusetts, United States
Dana-Farber Cancer Institute /ID# 152735
Boston, Massachusetts, United States
Washington University-School of Medicine /ID# 153671
St Louis, Missouri, United States
Columbia University Medical Center /ID# 153661
New York, New York, United States
Weill Cornell Medical College /ID# 155524
New York, New York, United States
Oregon Medical Research Center /ID# 152734
Portland, Oregon, United States
University of Pittsburgh MC /ID# 153662
Pittsburgh, Pennsylvania, United States
Tennessee Oncology-Nashville Centennial /ID# 222769
Nashville, Tennessee, United States
Vanderbilt University Medical Center /ID# 152738
Nashville, Tennessee, United States
UT MD Anderson Cancer Center /ID# 153809
Houston, Texas, United States
Concord Repatriation General Hospital /ID# 154958
Concord, New South Wales, Australia
Duplicate_St. Vincent's Hospital, Darlinghurst /ID# 222846
Darlinghurst, New South Wales, Australia
St George Hospital /ID# 154954
Kogarah, New South Wales, Australia
Liverpool Hospital /ID# 222410
Liverpool, New South Wales, Australia
Calvary Mater Newcastle /ID# 154957
Waratah, New South Wales, Australia
Duplicate_Princess Alexandra Hospital /ID# 154990
Woolloongabba, Queensland, Australia
Austin Health /ID# 154955
Heidelberg, Victoria, Australia
The Alfred Hospital /ID# 154956
Melbourne, Victoria, Australia
Fiona Stanley Hospital /ID# 222847
Murdoch, Western Australia, Australia
Juravinski Cancer Centre /ID# 152947
Hamilton, Ontario, Canada
Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 153828
Nantes, Pays de la Loire Region, France
Hôpital Saint-Louis /ID# 153827
Paris, France
Universitatsklinikum Mannheim /ID# 153140
Mannheim, Baden-Wurttemberg, Germany
Klinikum rechts der Isar /ID# 153139
Munich, Bavaria, Germany
Universitaetsklinikum Koeln /ID# 153141
Cologne, North Rhine-Westphalia, Germany
Duplicate_Universitaetsklinikum Carl Gus /ID# 153958
Dresden, Saxony, Germany
Universitaetsklinikum Leipzig /ID# 153142
Leipzig, Saxony, Germany
Universitaetsklinikum Halle (Saale) /ID# 153760
Halle, Germany
Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 153763
Bologna, Emilia-Romagna, Italy
Duplicate_Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 153764
Rome, Roma, Italy
Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 156492
Norwich, Norfolk, United Kingdom
Oxford University Hospitals NHS Foundation Trust /ID# 222567
Oxford, Oxfordshire, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 158810
Birmingham, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 156489
London, United Kingdom