Clinical Research Directory

Inclusion Criteria: * Documented diagnosis of type 2 diabetes mellitus * Both sexes were treated with oral antidiabetic agents and / or insulin except the current treatment with Glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase 4 inhibitors * Stable antidiabetic medication within the last 8 weeks prior to randomization (V2), if therapy includes insulin, the average daily dose should not have changed by more than 10% in the past 8 weeks * HbA1c\> 8.0% * Age\> 20 years and \<60 years * Body mass index (BMI) of 30 35 kg / m² * Agree to sign the consent form Exclusion Criteria: * Type 1 diabetes mellitus (positive for anti-GAD), or GAD negative anti anti body with low β cell function (C-peptide after stimulation \<0.5 ng / ml) * Current treatment with GLP-1 receptor agonist and / or dipeptidyl peptidase 4 inhibitors * Recent vascular event (myocardial infarction, coronary angioplasty or stroke in the past 6 months) * Malignant neoplasm * Portal hypertension * Inability to cooperate with segment * Low capacity of understanding surgery * Unrealistic expectations of the outcome * Cognitive impairment * Current pregnancy * Moderate or severe mood disorder; severe anxiety; eating disorders (based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria) * Chemical dependency or alcoholism (based on DSM-V criteria).