Clinical Research Directory

Inclusion Criteria: * age ≥ 18 * signed written informed consent * indication for a flexible bronchoscopy * DPLD characterized by clinical and radiological data compatible with : idiopathic pulmonary fibrosis (IPF), acute or chronic hypersensitivity pneumonitis (HPS), sarcoidosis, or asbestosis. * Initial histological confirmation of the disease is not required for the inclusion of the patient and the realisation of the alveolar bronchoscopy. * non-smoking or smoking cessation \>6 month * Patient affiliated with, or beneficiary of a social security category Exclusion Criteria: * respiratory failure and contraindication for a flexible bronchoscopy (this item will stay at the appreciation of the physician, arterial blood gaz sampling being not required) * bleeding disorder which would be not compatible with the realization of a flexible bronchoscopy * history of pneumonectomy or non functional lung controlateral to the pCLE procedure * patients for which a per-endoscopic distal lung cryobiopsy is forecasted during the first diagnostic bronchoscopy, * patients for which the bronchoscopy needs a general anesthesia and mechanical ventilation during the procedure * anticoagulant or platelet aggregation inhibitors that cannot be interrupted for the flexible bronchoscopy * patients for which a follow up or an adequate work-up to achieve the final diagnosis will not be possible. * patients for which a cryobiopsy is forecasted during the bronchoscopy * pregnant and breast feeding women, or women of childbearing potential not taking adequate contraception * Patients unable to understand informed consent * Patient on major legal measure of protection * Patients participating in an other interventional clinical trial at the inclusion date