Clinical Research Directory
Browse clinical research sites, groups, and studies.
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
Sponsor: Novartis Pharmaceuticals
Summary
The purpose of this study is to evaluate the long-term safety in patients with TSC and refractory seizures who are currently receiving everolimus treatment in the Novartis-sponsored EXIST-3 study and who are determined to be benefiting from continued treatment as judged by the investigator at the completion of EXIST-3
Official title: An Open-label, Multi-center Long-term Safety Roll-over Study in Patients With Tuberous Sclerosis Complex (TSC) and Refractory Seizures Who Are Judged by the Investigator to Benefit From Continued Treatment With Everolimus After Completion of Study CRAD001M2304.
Key Details
Gender
All
Age Range
2 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
206
Start Date
2017-06-08
Completion Date
2027-08-13
Last Updated
2026-04-02
Healthy Volunteers
No
Conditions
Interventions
everolimus
everolimus, 2mg dispersible tablets
Locations (68)
TGen APNNA
Phoenix, Arizona, United States
David Geffen School of Medicine at UCLA
Los Angeles, California, United States
UCSF Benioff Children s Hospital
Oakland, California, United States
Rady Children s Hospital
San Diego, California, United States
University of Colorado School of Medicine
Aurora, Colorado, United States
Connecticut Childrens Medical Cntr
Hartford, Connecticut, United States
University of Chicago Medical Center
Chicago, Illinois, United States
Minnesota Epilepsy Group
Saint Paul, Minnesota, United States
Atlantic Health Systems
Morristown, New Jersey, United States
Cinn Children Hosp Medical Center
Cincinnati, Ohio, United States
Oregon Health Sciences University
Portland, Oregon, United States
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Texas Scottish Rite Hos for Child
Dallas, Texas, United States
Texas Childrens Hospital
Houston, Texas, United States
Novartis Investigative Site
Sydney, New South Wales, Australia
Novartis Investigative Site
Nedlands, Western Australia, Australia
Novartis Investigative Site
Brussels, Belgium
Novartis Investigative Site
Brussels, Belgium
Novartis Investigative Site
Ghent, Belgium
Novartis Investigative Site
Leuven, Belgium
Novartis Investigative Site
Vancouver, British Columbia, Canada
Novartis Investigative Site
Cali, Valle del Cauca Department, Colombia
Novartis Investigative Site
Amiens, France
Novartis Investigative Site
Bron, France
Novartis Investigative Site
Lille, France
Novartis Investigative Site
Marseille, France
Novartis Investigative Site
Strasbourg, France
Novartis Investigative Site
Budapest, Hungary
Novartis Investigative Site
Bari, BA, Italy
Novartis Investigative Site
Bologna, BO, Italy
Novartis Investigative Site
Pavia, PV, Italy
Novartis Investigative Site
Roma, RM, Italy
Novartis Investigative Site
Siena, SI, Italy
Novartis Investigative Site
Suita, Osaka, Japan
Novartis Investigative Site
Shizuoka, Shizuoka, Japan
Novartis Investigative Site
Okayama, Japan
Novartis Investigative Site
Osaka, Japan
Novartis Investigative Site
Guadalajara, Jalisco, Mexico
Novartis Investigative Site
Warsaw, Poland
Novartis Investigative Site
Samara, Samara Oblast, Russia
Novartis Investigative Site
Moscow, Russia
Novartis Investigative Site
Moscow, Russia
Novartis Investigative Site
Voronezh, Russia
Novartis Investigative Site
Seoul, South Korea
Novartis Investigative Site
Seoul, South Korea
Novartis Investigative Site
Seoul, South Korea
Novartis Investigative Site
Donostia / San Sebastian, Gipuzkoa, Spain
Novartis Investigative Site
Barcelona, Spain
Novartis Investigative Site
Madrid, Spain
Novartis Investigative Site
Madrid, Spain
Novartis Investigative Site
Seville, Spain
Novartis Investigative Site
Valencia, Spain
Novartis Investigative Site
Kaohsiung City, Taiwan
Novartis Investigative Site
Tainan, Taiwan
Novartis Investigative Site
Taipei, Taiwan
Novartis Investigative Site
Bangkok, Thailand
Novartis Investigative Site
Bangkok, Thailand
Novartis Investigative Site
Bangkok, Thailand
Novartis Investigative Site
Istanbul, Fatih, Turkey (Türkiye)
Novartis Investigative Site
Ankara, Yenimahalle, Turkey (Türkiye)
Novartis Investigative Site
Birmingham, West Midlands, United Kingdom
Novartis Investigative Site
Buckinghamshire, United Kingdom
Novartis Investigative Site
Cambridge, United Kingdom
Novartis Investigative Site
Liverpool, United Kingdom
Novartis Investigative Site
London, United Kingdom
Novartis Investigative Site
London, United Kingdom
Novartis Investigative Site
Sheffield, United Kingdom
Novartis Investigative Site
York, United Kingdom