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Liver Function Investigation With SPECT
Sponsor: Royal North Shore Hospital
Summary
This is a Phase 1 pilot study to assess feasibility and utility of 99mTc-mebrofenin hepatobiliary scintigraphy for measurement of functional liver change due to radiotherapy.
Official title: Liver Function Investigation With Single Photon Emission Computed Tomography After Radiotherapy
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2016-10-19
Completion Date
2026-12-31
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
99mTc-mebrofenin hepatobiliary scintigraphy (HBS)
99mTc-mebrofenin HBS is a SPECT imaging procedure that allows evaluation of global and local liver function. Mebrofenin, bound to albumin, is taken up by hepatocytes in a similar manner to organic anions such as bilirubin. After hepatic uptake, the mebrofenin is excreted into the bile canaliculi. Dynamic imaging tools allow measurement of clearance rates for global function, and 3D SPECT imaging with corresponding CT allows visualisation of the local liver function with respect to anatomy. HBS allows direct visualisation of hepatocyte function.
Indocyanine Green
ICG is a fluorescent dye injected into the patient. The dye is exclusively excreted by the liver. The ICG clearance rate is measured in the finger of the subject.
Liver Elasticity
This is an Ultrasound measurement of the elasticity of the liver.
Locations (1)
Royal North Shore Hospital
St Leonards, New South Wales, Australia