Clinical Research Directory

Inclusion Criteria: For the HEALTHY participants 1. The participant has a minimum age of 65 years. 2. The participant is living independently or semi-independently at home, service flat or care home. 3. The participant has no subjective memory concern as reported by the participant, informant, or clinician. 4. The participant has a normal brain function documented by scoring above 27 on the MMSE, above 26 on the MOCA and has a score of 0 for the CDR. 5. In the opinion of the investigator, the participant is in stable medical condition and willing and able to perform study procedures in the opinion of the investigator. 6. The participant is fluent in written and verbal Dutch. For the participants with COGNITIVE IMPAIRMENT: 1. The participant has a minimum age of 65 years. 2. The participant is living independently or semi-independently at home, service flat or care home. 3. In the opinion of the investigator, the participant is in stable medical condition and willing and able to perform study procedures in the opinion of the investigator. 4. The participant is fluent in written and verbal Dutch. 5. For MCI: MCI patients, at baseline, are diagnosed applying Petersen's diagnostic criteria, i.e., (1) cognitive complaint, preferably corroborated by an informant; (2) objective cognitive impairment, quantified as performance of more than 1.5 SD below the appropriate mean on the neuropsychological subtests (z-score below -1.5); (3) largely normal general cognitive functioning; (4) essentially intact activities of daily living (ADL) (basic and instrumental activities of daily living (iADL) were determined by a clinical interview with the patient and an informant); and (5) not demented. 6. For AD:Probable AD according to the National Institute on Aging/Alzheimer's Association Diagnostic Guidelines Exclusion Criteria: \-