Clinical Research Directory

Inclusion Criteria: 1. Males and nonpregnant females (as indicated by a negative urine pregnancy test prior to first dose of vaccine) age 18 years and older. 2. Healthcare personnel at risk of mpox infection working in the Tshuapa Province of DRC or laboratory personnel performing diagnostic testing for mpox at the time of enrollment 3. Willing to adhere to infection control recommendations to the extent possible based on availability of resources. 4. Able and willing to complete the informed consent process and study procedures (including blood sample collection, urine pregnancy test, and completion of adverse event diary and exposure forms). 5. Available for all study visits. Exclusion Criteria: 1. Any history of allergy or anaphylaxis to any prior vaccines, eggs, or aminoglycosides. 2. Current pregnancy (a negative urine pregnancy test is required for women participants who self-report as not pregnant). Enrollment for such participants may be deferred to a later time at which this criteria can be met. 3. Acute illness that is accompanied by an axillary temperature ≥37.2°C (99.0°F) at the time of vaccination. Enrollment for such participants may be deferred to a later time at which this criteria can be met. 4. Known experimental research agents or other vaccine within 28 days (4 weeks) prior to vaccination. Enrollment for such participants may be deferred to a later time at which this criteria can be met. 5. Any reason the PIs suspect that data collected from this person would be incomplete or of poor quality. 6. Any condition that the PIs suspect may place the participant at an unacceptable risk of injury or render the participant unable to meet the requirements of the protocol.