Clinical Research Directory

Inclusion Criteria: Each participant must meet all the following inclusion criteria to be enrolled in the study: 1. Histologically confirmed CD30+ classical HL. 2. Advanced stage, newly diagnosed HL (Stage III and Stage IV disease). 3. Treatment-naive HL. 4. Have performance scores of greater than or equal to (\>=) 50 for Lansky Play-performance or Karnofsky Performance Status. 5. Have bidimensional measurable disease as documented by radiographic technique per International Working Group (IWG) criteria. 6. Have adequate blood counts, renal and liver function as defined in the protocol. Exclusion Criteria: 1. Nodular lymphocyte predominant HL. 2. Known active cerebral/meningeal disease, including signs or symptoms of progressive multifocal leukoencephalopathy (PML) or any history of PML. 3. Any sensory or motor peripheral neuropathy. 4. Symptomatic neurologic disease compromising normal activities of daily living or requiring medications. 5. Any active systemic viral, bacterial, or fungal infection requiring systemic antibiotics within 2 weeks before the first study protocol therapy. 6. Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient contained in the drug formulation of brentuximab vedotin or any component of AVD. 7. Known human immunodeficiency virus positive. 8. Known hepatitis B surface antigen positive or known or suspected active hepatitis C infection, as determined by hepatitis B DNA or hepatitis C RNA, respectively, in blood. 9. Diagnosed or treated for another malignancy within 3 years before the first dose or previously diagnosed with another malignancy and have any evidence of residual disease. Participants with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection. 10. Use of any strong or listed moderate cytochrome P450 (CYP) 3A4 inhibitors less than (\<) 2 weeks before the first dose of protocol therapy (please refer to the Study Manual for an example list of prohibited CYP3A4 inhibitors). 11. Any of the following cardiovascular conditions or values within 6 months before the first dose of protocol therapy: * Shortening fraction of \<27 percent (%) by echocardiogram or, if echocardiogram not feasible, ejection fraction of \<50% by radionuclide angiogram (RNA or MUGA \[multiple-gated acquisition scan\]). * New York Heart Association Class III or IV heart failure. * Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure, angina, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities.