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RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD
Sponsor: University of Calgary
Summary
This study examines the effect of the ultra long acting beta agonist/corticosteroid bronchodilator combination fluticasone furoate/vilanterol trifenatate, on respiratory muscles and ventilation in adults with severe bronchitis or emphysema (COPD).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2016-04
Completion Date
2026-07-01
Last Updated
2025-02-18
Healthy Volunteers
No
Conditions
Interventions
Ventilation
Measurements of ventilation with subjects seated, and breathing across a pneumotachygraph and pressure transducer to measure inspiratory airflow, during both resting and CO2 stimulated breathing.
Parasternal EMG
Recordings of electrical activity (EMG) from the parasternal intercostal muscle in the second intercostal space on the upper anterior chest wall adjacent to the sternum.
Phrenic magnetic stimulation
Bilateral maximal magnetic stimulation (Magstim) of the phrenic nerves.
Locations (1)
University of Calgary
Calgary, Alberta, Canada