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Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery
Sponsor: Institut de Cancérologie de Lorraine
Summary
This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope (Techniciun99) in the detection of sentinel lymph nodes will be assess using an "Optonuclear" probe (EURORAD S.A.) and QUEST camera
Official title: Reliability of Indocyanine Green Use in Sentinel Lymph Node Identification in Cancer Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
744
Start Date
2017-11-29
Completion Date
2022-10-12
Last Updated
2026-09-01
Healthy Volunteers
No
Conditions
Interventions
Indocyanine green
Each patient receive injection of indocyanine green just before surgery Specify total dose : 2.5 mg/ml (Intravenous use)
Technetium99
Each patient receives injection of Technetium 99 ( injected in subcutaneously) before surgery. Lymphoscintigraphy is performed to identify the sentinel node
Optonuclear probe
The detection of sentinel lymph node will be conducted by an optonuclear probe able to detect the radioactive and the fluorescence signal during surgery.
Quest Camera
The detection of sentinel lymph node will be conducted by a camera able to determine imagery of fluorescence during surgery.
Locations (1)
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France