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Study of Durvalumab Alone or Chemotherapy for Patients With Advanced Non Small-Cell Lung Cancer (PEARL)
Sponsor: AstraZeneca
Summary
This is a randomized, open-label, multi-center Phase III study to determine the efficacy and safety of durvalumab versus platinum-based SoC chemotherapy in the first-line treatment of advanced NSCLC in patients who are epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type and with PD-L1 high expression (PEARL)
Official title: A Phase III Randomized, Open-Label, Multi-Center Study of Durvalumab (MEDI4736) Versus Standard of Care (SoC) Platinum-Based Chemotherapy as First Line Treatment in Patients With PD-L1-High Expression Advanced Non Small-Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
669
Start Date
2017-01-02
Completion Date
2026-06-30
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
Durvalumab (MEDI4736)
Anti-PD-L1 monoclonal Antibody monotherapy
Paclitaxel + carboplatin
Chemotherapy Agents
Gemcitabine + cisplatin
Chemotherapy Agents
Gemcitabine + carboplatin
Chemotherapy Agents
Pemetrexed + cisplatin
Chemotherapy Agent
Pemetrexed + carboplatin
Chemotherapy Agent
Locations (92)
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Anaheim, California, United States
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Box Hill, Australia
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Gosford, Australia
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Kogarah, Australia
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St Leonards, Australia
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Beijing, China
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Beijing, China
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Beijing, China
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Bengbu, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Guangzhou, China
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Guangzhou, China
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Haikou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Jinan, China
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Linhai, China
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Nanchang, China
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Nanjing, China
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Ningbo, China
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Shanghai, China
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Shenyang, China
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Shijiazhuang, China
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Ürümqi, China
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Ürümqi, China
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Wanzhou, China
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Wenzhou, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Xi'an, China
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Zhengzhou, China
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Zhuhai, China
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Deszk, Hungary
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Farkasgyepü, Hungary
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Gyöngyös - Mátraháza, Hungary
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Székesfehérvár, Hungary
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Törökbálint, Hungary
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Almelo, Netherlands
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Bialystok, Poland
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Grudziądz, Poland
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Koszalin, Poland
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Lublin, Poland
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Mrozy, Poland
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Warsaw, Poland
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Wroclaw, Poland
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Arkhangelsk, Russia
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Moscow, Russia
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Novosibirsk, Russia
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Omsk, Russia
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Rostov-on-Don, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Volgograd, Russia
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Changwon-si, South Korea
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Cheongju-si, South Korea
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Daegu, South Korea
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Incheon, South Korea
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Jinju, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Taichung, Taiwan
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Taichung, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Muang, Thailand
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Songkhla, Thailand
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Ankara, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Malatya, Turkey (Türkiye)
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Pamukkale, Turkey (Türkiye)
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Can Tho, Vietnam
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Hanoi, Vietnam
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Hanoi, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam