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ACTIVE NOT RECRUITING

NCT03006068

PHASE3

A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

Sponsor: AbbVie

View on ClinicalTrials.gov

Summary

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

Official title: A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

Key Details

Gender

All

Age Range

16 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

950

Start Date

2017-01-31

Completion Date

2027-07

Last Updated

2026-01-12

Healthy Volunteers

Conditions

Ulcerative Colitis (UC)

Interventions

DRUG

Upadacitinib (ABT-494)

Upadacitinib (ABT-494) will be administered orally.

DRUG

Placebo

Placebo will be administered orally.

Inclusion Criteria: Note: Participants aged 16 or 17 may enroll in M14-234 or M14-675 where locally permissible * Participant has not achieved clinical response at the end of the induction period (Week 8) in Study M14-234 Substudy 1, has had loss of response during the maintenance period of Study M14-234 Substudy 3, or has successfully completed Study M14-234 Substudy 3. During the COVID-19 pandemic, for participants with missing endoscopy at Week 8, Week 16 or Week 52 due to the COVID-19 pandemic in Studies M14-234 Substudy 2, M14-234 Substudy 3 and M14-675, participants may be enrolled if certain criteria are met. * If female, participant must meet the contraception criteria. * Women of childbearing potential must have a negative urine pregnancy test at Week 0 visit. * Participant is judged to be in otherwise good health as determined by the principal investigator based upon clinical evaluations performed during the preceding study (Study M14-234). * Must be able and willing to give written informed consent and to comply with the requirements of this study protocol. Exclusion Criteria: * For any reason participant is considered by the investigator to be an unsuitable candidate. * Female participant with a positive pregnancy test at the final visit of Study M14-234 or who is considering becoming pregnant during the study or within 30 days after the last dose of study drug. * Known hypersensitivity to upadacitinib or its excipients or had any adverse event (AE) during the preceding studies, that in the investigator's judgment makes the participant unsuitable for this study. * Participant with an active or recurrent infection that based on the investigator's clinical assessment makes the participant an unsuitable candidate for the study. Participants with ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the infection has been successfully treated. * Current evidence of active tuberculosis (TB); current evidence of latent tuberculosis and for any reason the participant cannot take full course of TB prophylaxis treatment as required per protocol. * Participant with a poorly controlled medical condition, such as uncontrolled diabetes, unstable ischemic heart disease, moderate or severe congestive heart failure (New York Heart Association class III or IV), recent cerebrovascular accidents and any other condition which, in the opinion of the investigator or sponsor, would put the subject at risk by participation in this study. * Participants have malignancy, high-grade dysplasia, un-removed low-grade dysplasia of the gastrointestinal tract diagnosed at the endoscopy performed at the final visit of Study M14-234. * History of any malignancy except for successfully treated nonmelanoma skin cancer (NMSC) or localized carcinoma in situ of the cervix from evaluations performed in Study M14-234.

Locations (492)

East View Medical Research, LLC /ID# 171184

Mobile, Alabama, United States

CB Flock Research Corporation /ID# 165986

Mobile, Alabama, United States

Delsol Research Management, Ll /Id# 170130

Chandler, Arizona, United States

Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886

Mesa, Arizona, United States

Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823

Sun City, Arizona, United States

Adobe Clinical Research LLC /ID# 155249

Tucson, Arizona, United States

Duplicate_University of Arizona /ID# 150568

Tucson, Arizona, United States

Citrus Valley Gastroenterology /ID# 151915

Covina, California, United States

Newport Huntington Medical Group /ID# 217006

Huntington Beach, California, United States

UC San Diego Health System /ID# 155187

La Jolla, California, United States

United Medical Doctors /ID# 207467

Los Alamitos, California, United States

TLC Clinical Research Inc /ID# 216830

Los Angeles, California, United States

Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082

Los Angeles, California, United States

Facey Medical Foundation /ID# 203135

Mission Hills, California, United States

United Medical Doctors - Murrieta /ID# 151213

Murrieta, California, United States

Ventura County Gastroenterology Medical Group /ID# 163417

Oxnard, California, United States

Inland Empire Clinical Trials, LLC /ID# 216163

Rialto, California, United States

San Diego Clinical Trials /ID# 212121

San Diego, California, United States

Medical Assoc Research Grp /ID# 169149

San Diego, California, United States

Univ of California San Francis /ID# 164583

San Francisco, California, United States

Delta Waves, Inc. /ID# 151727

Colorado Springs, Colorado, United States

South Denver Gastroenterology /ID# 151224

Lone Tree, Colorado, United States

Western States Clinical Res /ID# 158078

Wheat Ridge, Colorado, United States

Duplicate_Western Connecticut Medical Group /ID# 169211

Danbury, Connecticut, United States

Gastroenterology Center of Connecticut /ID# 150534

Hamden, Connecticut, United States

West Central Gastroenterology /ID# 155242

Clearwater, Florida, United States

Moonshine Research Center, Inc /ID# 152534

Doral, Florida, United States

Universal Axon Clinical Research /ID# 213463

Doral, Florida, United States

Palmetto Research, LLC /ID# 151724

Hialeah, Florida, United States

Nature Coast Clinical Research - Inverness /ID# 154070

Inverness, Florida, United States

Encore Borland-Groover Clinical Research /Id# 170913

Jacksonville, Florida, United States

SIH Research Mumtaz, Inc /ID# 163199

Kissimmee, Florida, United States

Cfagi Llc /Id# 202018

Maitland, Florida, United States

Duplicate_University of Miami /ID# 215443

Miami, Florida, United States

Advanced Pharma CR, LLC /ID# 151723

Miami, Florida, United States

New Horizon Research Center /ID# 152475

Miami, Florida, United States

Crystal Pharmacology Research /ID# 151848

Miami, Florida, United States

Coral Research Clinic /ID# 150524

Miami, Florida, United States

Advanced Research Institute, Inc /ID# 163093

New Port Richey, Florida, United States

Endoscopic Research, Inc. /ID# 151725

Orlando, Florida, United States

Omega Research Group /ID# 200271

Orlando, Florida, United States

Clinical Research Trials of Florida, Inc. /ID# 201791

Tampa, Florida, United States

Duplicate_University of South Florida /ID# 214494

Tampa, Florida, United States

Duplicate_AdventHealth Tampa /ID# 200274

Tampa, Florida, United States

Gastroenterology Associates of Central Georgia, LLC /ID# 165783

Macon, Georgia, United States

Infinite Clinical Trials /ID# 215342

Riverdale, Georgia, United States

Atlanta Gastroenterology Spec /ID# 150565

Suwanee, Georgia, United States

Next Innovative Clinical Research - Chicago /ID# 217323

Chicago, Illinois, United States

Duplicate_The University of Chicago DCAM /ID# 150564

Chicago, Illinois, United States

Duplicate_NorthShore University HealthSystem /ID# 150570

Evanston, Illinois, United States

Northwest Health Care Associates /ID# 151591

Hoffman Estates, Illinois, United States

Carle Foundation Hospital /ID# 151155

Urbana, Illinois, United States

MediSphere Medical Research Center /ID# 152080

Evansville, Indiana, United States

Indianapolis Gastroenterology /ID# 162914

Indianapolis, Indiana, United States

University of Iowa Hospitals and Clinics /ID# 157059

Iowa City, Iowa, United States

Cotton O'Neil Clinical Research Center, Digestive Health /ID# 167183

Topeka, Kansas, United States

Tri-State Gastroenterology /ID# 169812

Crestview Hills, Kentucky, United States

Houma Digestive Health Special /ID# 151851

Houma, Louisiana, United States

Nola Research Works, LLC /ID# 153365

New Orleans, Louisiana, United States

Louisiana Research Center, LLC /ID# 150526

Shreveport, Louisiana, United States

University of Maryland, Baltimore /ID# 150529

Baltimore, Maryland, United States

Gastro Center of Maryland /ID# 200024

Columbia, Maryland, United States

Massachusetts General Hospital /ID# 165678

Boston, Massachusetts, United States

University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158

Ann Arbor, Michigan, United States

Huron Gastroenterology Assoc /ID# 152712

Ann Arbor, Michigan, United States

Clin Res Inst of Michigan, LLC /ID# 153031

Chesterfield, Michigan, United States

Clin Res Inst of Michigan, LLC /ID# 161983

Chesterfield, Michigan, United States

Revival Research Institute, LLC /ID# 207281

Southfield, Michigan, United States

Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487

Wyoming, Michigan, United States

Mayo Clinic - Rochester /ID# 151681

Rochester, Minnesota, United States

Minnesota Gastroenterology PA /ID# 151682

Saint Paul, Minnesota, United States

University of Mississippi Medical Center /ID# 213140

Jackson, Mississippi, United States

Southern Therapy and Advanced Research (STAR) LLC /ID# 170713

Jackson, Mississippi, United States

Washington University-School of Medicine /ID# 150537

St Louis, Missouri, United States

Vector Clinical Trials /ID# 153052

Las Vegas, Nevada, United States

Dartmouth-Hitchcock Medical Center /ID# 150566

Lebanon, New Hampshire, United States

Cooper Gastroenterology at Fire Road /ID# 153048

Egg Harbor, New Jersey, United States

Atlantic Digestive Health Inst /ID# 150527

Morristown, New Jersey, United States

Rutgers Robert Wood Johnson /ID# 155247

New Brunswick, New Jersey, United States

Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399

Albuquerque, New Mexico, United States

NY Scientific /ID# 152708

Brooklyn, New York, United States

Duplicate_NYU Langone Long Island Clinical Research Association /ID# 155271

Great Neck, New York, United States

Columbia Univ Medical Center /ID# 163409

New York, New York, United States

Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 201534

North Massapequa, New York, United States

Premier Medical Group - GI Division /ID# 153366

Poughkeepsie, New York, United States

Gastoenterology Group of Rochester /ID# 151080

Rochester, New York, United States

Richmond University Medical Center /ID# 201860

Staten Island, New York, United States

Montefiore Medical Center - Moses Campus /ID# 150559

The Bronx, New York, United States

Advantage Clinical Trials /ID# 163940

The Bronx, New York, United States

Digestive Health Partners - Biltmore Office /ID# 167238

Asheville, North Carolina, United States

Atrium Health Carolinas Medical Center /ID# 157060

Charlotte, North Carolina, United States

Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561

Charlotte, North Carolina, United States

Atlantic Gastroenterology Clinical Research /ID# 151901

Greenville, North Carolina, United States

Clinical Trials of America /ID# 153453

Winston-Salem, North Carolina, United States

Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 150528

Winston-Salem, North Carolina, United States

Plains Clinical Research Center, LLC /ID# 170291

Fargo, North Dakota, United States

Gastro Health Research /ID# 151683

Cincinnati, Ohio, United States

University Of Cincinnati Medical Center /ID# 164584

Cincinnati, Ohio, United States

The Ohio State University /ID# 169417

Columbus, Ohio, United States

Optimed Research, Ltd. /ID# 169697

Columbus, Ohio, United States

Hometown Urgent Care and Resea /ID# 200066

Dayton, Ohio, United States

Dayton Gastroenterology, Inc. /ID# 167632

Englewood, Ohio, United States

Great Lakes Gastroenterology Research, LLC /ID# 201773

Mentor, Ohio, United States

Ohio Clinical Research Partner /ID# 154074

Mentor, Ohio, United States

Hightower Clinical /ID# 216338

Oklahoma City, Oklahoma, United States

Digestive Disease Specialists /ID# 201057

Oklahoma City, Oklahoma, United States

Options Health Research, LLC /ID# 150569

Tulsa, Oklahoma, United States

Healthcare Research Consultant /ID# 163096

Tulsa, Oklahoma, United States

Northwest Gastroenterology Clinic /ID# 152528

Portland, Oregon, United States

Guthrie Medical Group, PC /ID# 150533

Sayre, Pennsylvania, United States

Penn State Health Colonnade /ID# 150267

State College, Pennsylvania, United States

Pharmacorp Clinical Trials /ID# 153363

Charleston, South Carolina, United States

Gastroenterology Associates, P.A. of Greenville /ID# 150557

Greenville, South Carolina, United States

Gastro One /ID# 151154

Cordova, Tennessee, United States

Duplicate_East Tennessee Research Institute /ID# 203611

Johnson City, Tennessee, United States

Quality Medical Research /ID# 203427

Nashville, Tennessee, United States

Vanderbilt University Medical Center /ID# 153364

Nashville, Tennessee, United States

TX Clinical Research Institute /ID# 151528

Arlington, Texas, United States

Inquest Clinical Research /ID# 164636

Baytown, Texas, United States

Texas Digestive Disease Consultants /ID# 209949

Cedar Park, Texas, United States

GI Alliance /ID# 209806

Cedar Park, Texas, United States

Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771

Dallas, Texas, United States

Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 151221

Garland, Texas, United States

Vilo Research Group Inc /ID# 212626

Houston, Texas, United States

CliniCore International, LLC /ID# 152078

Houston, Texas, United States

Duplicate_Baylor College of Medicine - Baylor Medical Center /ID# 150538

Houston, Texas, United States

Centex Studies, Inc. - Houston /ID# 201217

Houston, Texas, United States

GI Specialists of Houston /ID# 202337

Houston, Texas, United States

Duplicate_Caprock Gastro Research, LLC /ID# 215116

Lubbock, Texas, United States

Clinical Associates in Research Therapeutics of America, LLC /ID# 167954

San Antonio, Texas, United States

Southern Star Research Institute, LLC /ID# 169397

San Antonio, Texas, United States

Carl R. Meisner Medical Clinic /ID# 171270

Sugar Land, Texas, United States

Baylor Scott & White Center for Diagnostic Medicine /ID# 204777

Temple, Texas, United States

Tyler Research Institute, LLC /ID# 169147

Tyler, Texas, United States

Gastro Health & Nutrition - Victoria /ID# 167764

Victoria, Texas, United States

HP Clinical Research /ID# 163941

Bountiful, Utah, United States

Advanced Research Institute /ID# 162640

Ogden, Utah, United States

Utah Gastroenternology - St. Mark's Office /ID# 163097

Salt Lake City, Utah, United States

Duplicate_Velocity Clinical Research - Salt Lake City /ID# 163180

West Jordan, Utah, United States

Ctr for Gastrointestinal Healt /ID# 153369

Franklin, Virginia, United States

Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 163630

Bellevue, Washington, United States

Virginia Mason Hospital & Medical Center /ID# 153030

Seattle, Washington, United States

The Polyclinic /ID# 165117

Seattle, Washington, United States

The Vancouver Clinic, INC. PS /ID# 162334

Vancouver, Washington, United States

Aurora Medical Center - Grafto /ID# 151726

Grafton, Wisconsin, United States

Wisconsin Center for Advanced Research /ID# 151845

Milwaukee, Wisconsin, United States

Duplicate_Medical College of Wisconsin /ID# 151850

Milwaukee, Wisconsin, United States

Hospital Britanico de Buenos Aires /ID# 209496

Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina

Cardio Alem /ID# 211281

San Isidro, Buenos Aires, Argentina

Gedyt /ID# 210016

Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina

Mautalen Salud e Investigacion /ID# 171174

Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina

Sanatorio 9 de Julio /ID# 150215

San Miguel de Tucumán, Tucumán Province, Argentina

Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 164186

Córdoba, Argentina

Macquarie University Hospital /ID# 211953

Macquarie University, New South Wales, Australia

Mater Misericordiae Limited /ID# 212686

South Brisbane, Queensland, Australia

Griffith University /ID# 211954

Southport, Queensland, Australia

Monash Health - Monash Medical Centre /ID# 150218

Clayton, Victoria, Australia

St Vincent's Hospital Melbourne /ID# 152503

Fitzroy Melbourne, Victoria, Australia

Fiona Stanley Hospital /ID# 211641

Murdoch, Western Australia, Australia

Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462

Linz, Upper Austria, Austria

Klinik Landstrasse /ID# 162867

Vienna, Vienna, Austria

Medizinische Universitaet Wien /ID# 150616

Vienna, Vienna, Austria

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 150463

Salzburg, Austria

Vitebsk Regional Advanced Clin /ID# 169592

Vitebsk, Belarus

Universitair Ziekenhuis Leuven /ID# 150468

Leuven, Vlaams-Brabant, Belgium

AZ-Delta /ID# 150467

Roeselare, West-Vlaanderen, Belgium

AZ Maria Middelares /ID# 150466

Ghent, Belgium

Duplicate_University Clinical Centre of the Republic of Srpska /ID# 150223

Banja Luka, Republika Srpska, Bosnia and Herzegovina

Duplicate_University Clinical Centre of the Republic of Srpska /ID# 150712

Banja Luka, Republika Srpska, Bosnia and Herzegovina

University Clinical Center Tuzla /ID# 150224

Tuzla, Tuzlanski, Bosnia and Herzegovina

University Clinical Hospital Mostar /ID# 150711

Mostar, Bosnia and Herzegovina

Clinical Center University of Sarajevo /ID# 150222

Sarajevo, Bosnia and Herzegovina

Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744

Goiânia, Goiás, Brazil

Faculdade de Medicina do ABC /ID# 152489

Santo André, La Spezia, Brazil

Hospital Nossa Senhora das Graças /ID# 152488

Curitiba, Paraná, Brazil

Hospital de Clinicas de Porto Alegre /ID# 153745

Porto Alegre, Rio Grande do Sul, Brazil

Upeclin Fmb - Unesp /Id# 152493

Botucatu, São Paulo, Brazil

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 152492

Ribeirão Preto, São Paulo, Brazil

Kaiser Clinica e Hospital Dia /ID# 152491

São José do Rio Preto, São Paulo, Brazil

University of Calgary /ID# 151818

Calgary, Alberta, Canada

Allen Whey Khye Lim Professional Corporation /ID# 211169

Edmonton, Alberta, Canada

University of Alberta Hospital /ID# 151824

Edmonton, Alberta, Canada

Covenant Health /ID# 158931

Edmonton, Alberta, Canada

OCT Research ULC /ID# 153179

Kelowna, British Columbia, Canada

Percuro Clinical Research, Ltd /ID# 150479

Victoria, British Columbia, Canada

Medicor Research Inc /ID# 151825

Greater Sudbury, Ontario, Canada

Duplicate_Hamilton Health Sciences -McMaster University Medical Centre /ID# 150477

Hamilton, Ontario, Canada

Ottawa Hospital Research Institute /ID# 151817

Ottawa, Ontario, Canada

Toronto Digestive Disease Associates /ID# 150475

Vaughan, Ontario, Canada

CISSS de la Monteregie /ID# 159271

Greenfield Park, Quebec, Canada

Duplicate_CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 150473

Lévis, Quebec, Canada

Recherche GCP Research /ID# 151819

Montreal, Quebec, Canada

Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 167170

Montreal, Quebec, Canada

Montreal General Hospital - McGill University Health Centre /ID# 170013

Montreal, Quebec, Canada

CIUSSS de l'Estrie - CHUS /ID# 150478

Sherbrooke, Quebec, Canada

Hospital Guillermo Grant Benavente de Concepción /ID# 212425

Concepción, Bio-Bio, Chile

CTR Estudios Clinicos /ID# 200111

Providencia, Region Metropolitana Santiago, Chile

M y F Estudios Clínicos /ID# 200112

Santiago, Region Metropolitana Santiago, Chile

Centro de Investigaciones Clínicas Viña del Mar /ID# 150226

Viña del Mar, Región de Valparaíso, Chile

Research Group /ID# 203177

Santiago, Santiago Metropolitan, Chile

Hospital Clinico Universidad De Los Andes /ID# 207427

Santiago, Chile

The First Affiliated Hospital, Sun Yat-sen University /ID# 150517

Guangzhou, Guangdong, China

The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 150518

Guangzhou, Guangdong, China

Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407

Shiyan, Hubei, China

Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089

Wuhan, Hubei, China

Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079

Wuhan, Hubei, China

Duplicate_Xiangya Hospital Central South University /ID# 167230

Changsha, Hunan, China

The First Affiliated Hospital of Nanchang University /ID# 212185

Nanchang, Jiangxi, China

The First Hospital of Jilin University /ID# 210087

Changchun, Jilin, China

Shengjing Hospital of China Medical University /ID# 166921

Shenyang, Liaoning, China

Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523

Shanghai, Shanghai Municipality, China

Shanghai Tenth People's Hospital /ID# 150522

Shanghai, Shanghai Municipality, China

Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826

Shanghai, Shanghai Municipality, China

West China Hospital, Sichuan University /ID# 167041

Chengdu, Sichuan, China

Tianjin Medical University General Hospital /ID# 170605

Tianjin, Tianjin Municipality, China

The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 165813

Hangzhou, Zhejiang, China

Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516

Hangzhou, Zhejiang, China

Hospital Universitario de San /ID# 155388

Medellín, Antioquia, Colombia

Coorp Hosp Juan Ciudad Sede Hospital Universitario Mayor Mederi /ID# 152811

Bogota DC, Cundinamarca, Colombia

Imat Oncomedica /ID# 207052

Montería, Departamento de Córdoba, Colombia

Duplicate_Poliklinika Solmed /ID# 211567

Grad Zagreb, City of Zagreb, Croatia

Klinicka bolnica Dubrava Zagreb /ID# 150228

Zagreb, City of Zagreb, Croatia

Klinicki bolnicki centar Zagreb /ID# 150262

Zagreb, City of Zagreb, Croatia

Klinicki bolnicki centar Zagreb /ID# 150715

Zagreb, City of Zagreb, Croatia

Duplicate_Klinicki bolnicki centar Osijek /ID# 150229

Osijek, County of Osijek-Baranja, Croatia

Klinicki bolnicki centar Rijeka /ID# 150714

Rijeka, Primorje-Gorski Kotar County, Croatia

Klinicki Bolnicki Centar (KBC) Split /ID# 213989

Split, Split-Dalmatia County, Croatia

Zadar General Hospital /ID# 150261

Zadar, Croatia

Iscare Klinické Centrum /ID# 209279

Prague, Praha 9, Czechia

Hepato-Gastroenterologie HK, s.r.o. /ID# 150946

Hradec Králové, Czechia

CTCenter MaVe s.r.o. /ID# 150903

Olomouc, Czechia

ARTROSCAN s.r.o. /ID# 150502

Ostrava, Czechia

Nemocnice Pardubickeho kraje, a.s. /ID# 213541

Pardubice, Czechia

Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224

Prague, Czechia

Axon Clinical, s.r.o. /ID# 152477

Prague, Czechia

North Estonia Medical Centre /ID# 160871

Mustamäe, Harju, Estonia

West Tallinn Central Hospital /ID# 150490

Tallinn, Harju, Estonia

East Tallinn Central Hospital - Magdaleena Unit /ID# 150488

Tallinn, Harju, Estonia

Tartu University Hospital /ID# 150489

Tartu, Estonia

Tampereen yliopistollinen sairaala /ID# 150376

Tampere, Pirkanmaa, Finland

Turku University Hospital /ID# 169895

Turku, Southwest Finland, Finland

Duplicate_Helsinki Univ Central Hospital /ID# 154283

Helsinki, Finland

Keski-Suomen Sairaala Nova /ID# 155665

Jyväskylä, Finland

Laakarikeskus Ikioma /ID# 150377

Mikkeli, Finland

Chu de Nice-Hopital Larchet Ii /Id# 152608

Nice, Alpes-Maritimes, France

CHU Montpellier - Hopital Saint Eloi /ID# 200088

Montpellier, Herault, France

CHRU Lille - Hopital Claude Huriez /ID# 152609

Lille, Nord, France

HCL - Hopital Lyon Sud /ID# 152540

Pierre-Bénite, Rhone, France

Centre Hospitalier Departemental Vendee (Chd Vendee) /ID# 165749

La Roche-sur-Yon, Vendee, France

CHU de Saint-Etienne, Hopital Nord /ID# 165756

Saint-Etienne, France

Universitatsklinikum Mannheim /ID# 150405

Mannheim, Baden-Wurttemberg, Germany

Universitaetsklinikum Tuebingen /ID# 151698

Tübingen, Baden-Wurttemberg, Germany

Duplicate_Agaplesion Markus Krankenhaus /ID# 161870

Frankfurt am Main, Hesse, Germany

Duplicate_Universitaetsklinikum Muenster /ID# 150402

Munster, Lower Saxony, Germany

Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575

Herne, North Rhine-Westphalia, Germany

Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812

Saarbrücken, Saarland, Germany

Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871

Kiel, Schleswig-Holstein, Germany

MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697

Berlin, Germany

Medizinisches Versorgungszentrum Portal 10 /ID# 207136

Münster, Germany

Praxis medicum /ID# 150404

Wiesbaden, Germany

General Hospital of Athens Laiko /ID# 208672

Athens, Attica, Greece

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101

Athens, Attica, Greece

University General Hospital of Heraklion PA.G.N.I /ID# 150236

Heraklion, Crete, Greece

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406

Athens, Greece

University General Hospital of Ioannina /ID# 164247

Ioannina, Greece

Theageneio Anticancer Hospital /ID# 164187

Thessaloniki, Greece

General Hospital of Thessaloniki Hippokrateio /ID# 209522

Thessaloniki, Greece

Meditres Kft. /ID# 151597

Kecskemét, Bács-Kiskun county, Hungary

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 150410

Szombathely, Vas County, Hungary

Bekes Megyei Kozponti Korhaz /ID# 151601

Békéscsaba, Hungary

Semmelweis Egyetem /ID# 150409

Budapest, Hungary

Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599

Sopron, Hungary

Mentahaz Maganorvosi Kozpont /ID# 206977

Székesfehérvár, Hungary

St James Hospital /ID# 150413

Dublin, Dublin, Ireland

St Vincents University Hospital /ID# 150411

Elm Park, Dublin, Ireland

Mercy University Hospital /ID# 153794

Cork, Ireland

Beaumont Hospital /ID# 150414

Dublin, Ireland

University Hospital Galway /ID# 150412

Galway, Ireland

Shaare Zedek Medical Center /ID# 163139

Jerusalem, Jerusalem, Israel

Hadassah Medical Center-Hebrew University /ID# 165119

Jerusalem, Jerusalem, Israel

Soroka University Medical Center /ID# 156562

Beersheba, Southern District, Israel

Rambam Health Care Campus /ID# 150416

Haifa, Israel

Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 150424

Bologna, Emilia-Romagna, Italy

IRCCS Istituto Clinico Humanitas /ID# 151363

Rozzano, Lombardy, Italy

ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605

Milan, Milano, Italy

ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673

Rho, Milano, Italy

Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 150425

Rome, Roma, Italy

Duplicate_Azienda Ospedaliera San Camillo Forlanini /ID# 151362

Rome, Roma, Italy

Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420

Rome, Roma, Italy

IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726

Negrar, Verona, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 150421

Milan, Italy

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 150263

Palermo, Italy

Aichi Medical University Hospital /ID# 151994

Nagakute, Aichi-ken, Japan

Nagoya University Hospital /ID# 152728

Nagoya, Aichi-ken, Japan

Nagoya City University Hospital /ID# 151949

Nagoya, Aichi-ken, Japan

Toyohashi Municipal Hospital /ID# 171470

Toyohashi, Aichi-ken, Japan

Ieda Hospital /ID# 157782

Toyota-shi, Aichi-ken, Japan

National Hospital Organization Hirosaki General Medical Center /ID# 152761

Hirosaki-shi, Aomori, Japan

Tokatsu Tsujinaka Hospital /ID# 214964

Abiko-shi, Chiba, Japan

Tsujinaka Hospital - Kashiwanoha /ID# 209572

Kashiwa-shi, Chiba, Japan

Toho University Sakura Medical Center /ID# 151935

Sakura-shi, Chiba, Japan

Juntendo University Urayasu Hospital /ID# 208783

Urayasu-shi, Chiba, Japan

Fukui Prefectural Hospital /ID# 210450

Fukui-shi, Fukui, Japan

Fukuoka University Chikushi Hospital /ID# 152627

Chikushino-shi, Fukuoka, Japan

Saiseikai Fukuoka Genaral Hospital /ID# 209481

Fukuoka, Fukuoka, Japan

Kyushu University Hospital /ID# 152525

Fukuoka, Fukuoka, Japan

Duplicate_Kitakyushu Municipal Medical Center /ID# 152589

Kitakyushu, Fukuoka, Japan

Kurume University Hospital /ID# 151977

Kurume-shi, Fukuoka, Japan

Ogaki Municipal Hospital /ID# 208226

Ogaki-shi, Gifu, Japan

National Hospital Organization Fukuyama Medical Center /ID# 206294

Fukuyama-shi, Hiroshima, Japan

Hiroshima University Hospital /ID# 151952

Hiroshima, Hiroshima, Japan

Duplicate_Asahikawa Medical University Hospital /ID# 170281

Asahikawa-shi, Hokkaido, Japan

Obihiro kosei Hospital /ID# 210425

Obihiro-shi, Hokkaido, Japan

Sapporo Tokushukai Hospital /ID# 209449

Sapporo, Hokkaido, Japan

Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705

Sapporo, Hokkaido, Japan

Sapporo Medical University Hospital /ID# 206493

Sapporo, Hokkaido, Japan

Sapporo Higashi Tokushukai Hospital /ID# 208495

Sapporo, Hokkaido, Japan

Aoyama Clinic /ID# 152048

Kobe, Hyōgo, Japan

Duplicate_Hyogo Medical University Hospital /ID# 152433

Nishinomiya-shi, Hyōgo, Japan

Duplicate_National Hospital Organization Mito Medical Center /ID# 152626

Higashi Ibaraki-gun, Ibaraki, Japan

Kanazawa University Hospital /ID# 207810

Kanazawa, Ishikawa-ken, Japan

Iwate Medical University Uchimaru Medical Center /ID# 203412

Morioka, Iwate, Japan

Imamura General Hospital /ID# 227138

Kagoshima, Kagoshima-ken, Japan

Idzuro Imamura Hospital /ID# 207640

Kagoshima, Kagoshima-ken, Japan

Sameshima Hospital /ID# 206673

Kagoshima, Kagoshima-ken, Japan

Kagoshima IBD Gastroenterology Clinic /ID# 245222

Kagoshima, Kagoshima-ken, Japan

St Marianna University School Of Medicine /ID# 209452

Kawasaki-shi, Kanagawa, Japan

SHOWA Medical University Fujigaoka Hospital /ID# 208223

Yokohama, Kanagawa, Japan

Yokohama City University Medical Center /ID# 169900

Yokohama, Kanagawa, Japan

Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358

Kyoto, Kyoto, Japan

Kyoto University Hospital /ID# 211808

Kyoto, Kyoto, Japan

Mie University Hospital /ID# 207253

Tsu, Mie-ken, Japan

Yokkaichi Hazu Medical Center /ID# 214349

Yokkaichi-shi, Mie-ken, Japan

National Hospital Organization Sendai Medical Center /ID# 209529

Sendai, Miyagi, Japan

NHO Nagasaki Medical Center /ID# 210821

Omura-shi, Nagasaki, Japan

Kenseikai Dongo Hospital /ID# 208102

Yamatotakada-shi, Nara, Japan

Saiseikai Niigata Hospital /ID# 209923

Niigata, Niigata, Japan

Duplicate_Niigata University Medical & Dental Hospital /ID# 218050

Niigata, Niigata, Japan

Ishida Clinic of IBD and Gastroenterology /ID# 210118

Ōita, Oita Prefecture, Japan

Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820

Kurashiki-shi, Okayama-ken, Japan

Duplicate_Okayama University Hospital /ID# 217924

Okayama, Okayama-ken, Japan

Kinshukai Infusion Clinic /ID# 207866

Osaka, Osaka, Japan

Kitano Hospital, Tazuke Kofukai Medical Research Institute /ID# 210396

Osaka, Osaka, Japan

Osaka City General Hospital /ID# 152703

Osaka, Osaka, Japan

Osaka Red Cross Hospital /ID# 209477

Osaka, Osaka, Japan

Osaka Metropolitan University Hospital /ID# 152681

Osaka, Osaka, Japan

Shoyukai Fujita Gastroenterological Hospital /ID# 216494

Takatsuki-shi, Osaka, Japan

Toyonaka Municipal Hospital /ID# 217083

Toyonaka-shi, Osaka, Japan

Duplicate_Saga University Hospital /ID# 209272

Saga, Saga-ken, Japan

Saitama Medical Center /ID# 152019

Kawagoe, Saitama, Japan

Tokitokai Tokito clinic /ID# 152676

Saitama-shi, Saitama, Japan

National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711

Higashi-ohmi-shi, Shiga, Japan

Shimane University Hospital /ID# 208906

Izumo-shi, Shimane, Japan

Hamamatsu University Hospital /ID# 205709

Hamamatsu, Shizuoka, Japan

NHO Shizuoka Medical Center /ID# 163571

Sunto-gun, Shizuoka, Japan

Institute of Science Tokyo Hospital /ID# 152017

Bunkyo-ku, Tokyo, Japan

St. Lukes International Hospital /ID# 208075

Chuo-ku, Tokyo, Japan

Tokai University Hachioji Hospital /ID# 152584

Hachioji-shi, Tokyo, Japan

Kitasato University Kitasato Institute Hospital /ID# 152687

Minato-ku, Tokyo, Japan

Kyorin University Hospital /ID# 153195

Mitaka-shi, Tokyo, Japan

Duplicate_Center hospital of the National Center for Global Health and Medicine /ID# 209533

Shinjuku-ku, Tokyo, Japan

Duplicate_Tokyo Women's Medical University Hospital /ID# 205978

Shinjuku-ku, Tokyo, Japan

Yamagata University Hospital /ID# 171468

Yamagata, Yamagata, Japan

Tokuyama Central Hospital /ID# 216995

Shunan-shi, Yamaguchi, Japan

Yamanashi Prefectural Central Hospital /ID# 151909

Kofu, Yamanashi, Japan

Teikyo University Hospital /ID# 209865

Tokyo, Japan

VCA Polyclinic Aura /ID# 150436

Riga, Latvia

Pauls Stradins Clinical University Hospital /ID# 153183

Riga, Latvia

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439

Kaunas, Lithuania

Klaipeda university hospital /ID# 163501

Klaipėda, Lithuania

Klaipeda University Hospital /ID# 163719

Klaipėda, Lithuania

Duplicate_Vilnius University Hospital /ID# 164172

Vilnius, Lithuania

Hospital Sultanah Bahiyah /ID# 152310

Alor Star, Kedah, Malaysia

Hospital Ampang /ID# 152311

Ampang, Selangor, Malaysia

Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313

Kuala Lumpur, Selangor, Malaysia

Uni Malaya MC /ID# 150440

Kuala Lumpur, Malaysia

Morales Vargas Centro de Investigacion S.C. /ID# 211327

León, Guanajuato, Mexico

Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 202334

Guadalajara, Jalisco, Mexico

Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265

Monterrey, Nuevo León, Mexico

Radboud Universitair Medisch Centrum /ID# 151701

Nijmegen, Gelderland, Netherlands

Amsterdam UMC, locatie AMC /ID# 150617

Amsterdam, North Holland, Netherlands

Leids Universitair Medisch Centrum /ID# 152625

Leiden, South Holland, Netherlands

Duplicate_Erasmus Medisch Centrum /ID# 150619

Rotterdam, South Holland, Netherlands

Universitair Medisch Centrum Utrecht /ID# 152776

Utrecht, Netherlands

Akershus Universitetssykehus_MAIN /ID# 150622

Lorenskog, Akershus, Norway

Universitetssykehuset I Nord-Norge /ID# 152836

Tromsø, Troms, Norway

Gastromed Sp. z o.o /ID# 216198

Torun, Kuyavian-Pomeranian Voivodeship, Poland

Centrum Zdrowia MDM /ID# 150626