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Prognostic and Predictive Biomarkers in Ovarian Cancers
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Summary
The investigators therefore propose to conduct a biological study of prospectively collected patient tumour samples, ascites, blood and other residual samples (feces, urine, vaginal smear) throughout the disease course where markers (at diagnosis and their change with treatment) will be correlated to outcome in order to investigate how genetic diversity in OC prior to treatment and adaptation following treatment contribute to chemotherapy resistance. In addition freshly collected ascitic samples (and tumour samples) will be subjected to ex vivo DNA repair functional assays and isolated in primary culture (and established as xenografts) for target validation experiments.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
350
Start Date
2016-09-26
Completion Date
2032-09
Last Updated
2026-03-20
Healthy Volunteers
No
Conditions
Interventions
Blood sample
Locations (1)
Gustave Roussy
Villejuif, Val de Marne, France