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Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
Sponsor: Peking University First Hospital
Summary
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes. The investigators hypothesize that dexmedetomidine supplemented analgesia in elderly patients after cancer surgery may help to maintain immune function and improve long-term outcomes, possibly by relieving stress and inflammatory response, improving analgesic efficacy and sleep quality, and reducing delirium incidence.
Official title: Impact of Dexmedetomidine Supplemented Analgesia on Long-term Survival in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
65 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
1500
Start Date
2017-01-06
Completion Date
2026-12-11
Last Updated
2026-07-28
Healthy Volunteers
No
Interventions
Dexmedetomidine supplemented morphine analgesia
Patients in this group receive patient-controlled intravenous analgesia for 3 days after surgery. The formula is a mixture of dexmedetomidine (1.25 ug/ml) and morphine (0.5 mg/ml), diluted with normal saline to 160 ml. 5-HT3 receptor antagonist is added when necessary. The analgesic pump is set to administer a background infusion at a rate of 1 ml/h, with a bolus dose of 2 ml at each time and a lockout time from 6 to 8 minutes.
Morphine analgesia
Patients in this group receive patient-controlled intravenous analgesia for 3 days after surgery. The formula is morphine (0.5 mg/ml), diluted with normal saline to 160 ml. 5-HT3 receptor antagonist is added when necessary. The analgesic pump is set to administer a background infusion at a rate of 1 ml/h, with a bolus dose of 2 ml at each time and a lockout time from 6 to 8 minutes.
Locations (12)
Peking University First Hospital
Beijing, Beijing Municipality, China
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Beijing, Beijing Municipality, China
Peking University International Hospital , , China, Contact:
Beijing, Beijing Municipality, China
Chongqing University Fuling Hospital
Chongqing, Chongqing Municipality, China
Guizhou Provincial People's Hospital , China, Contact:
Guiyang, Guizhou, China
Affiliated Hospital of Hebei University
Baoding, Hebei, China
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China
The Second Affiliated Hospital of Air Force Medical University
Xi'an, Shaanxi, China
Qingdao Municipal Hospital , , China, Contact:
Qingdao, Shandong, China
Shanxi Provincial Cancer Hospital , China, Contact:
Taiyuan, Shanxi, China
Tianjin Hospital of ITCWM-Nankai Hospital
Tianjin, Tianjin Municipality, China
The Third Central Hospital of Tianjin
Tianjin, Tianjin Municipality, China