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B Cell Lymphocyte in Humoral Rejection and Alloimmunisation
Sponsor: University Hospital, Brest
Summary
This study aims to better characterise B cell phenotype and functional abnormalities in kidney transplant patients producing donor specific antibody (DSA) and in those with chronic antibody mediated rejection (cAMR) and to search for a predictive tool (biomarker). The functional analysis will help to better understand B cell-dependant mechanisms implied in T cell proliferation and better target future treatments.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
116
Start Date
2013-06-13
Completion Date
2016-12-12
Last Updated
2026-06-08
Healthy Volunteers
No
Conditions
Interventions
Presence of DSA w/ cAMR
Presence of DSA w/o cAMR
No DSA No cAMR
Locations (13)
CHU Amiens
Amiens, France
Chu Angers
Angers, France
CHU Brest
Brest, France
CHU CAEN
Caen, France
Chu Clermont Ferrand
Clermont-Ferrand, France
CHU Limoges
Limoges, France
APHP Hôpital Necker
Paris, France
CHU Poitiers
Poitiers, France
CHU Reims
Reims, France
CHU Rennes
Rennes, France
CHU Rouen
Rouen, France
Hôpitaux Universitaires de Strasbourg
Strasbourg, France
CHU Tours
Tours, France