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COMPLETED
NCT03016455

B Cell Lymphocyte in Humoral Rejection and Alloimmunisation

Sponsor: University Hospital, Brest

View on ClinicalTrials.gov

Summary

This study aims to better characterise B cell phenotype and functional abnormalities in kidney transplant patients producing donor specific antibody (DSA) and in those with chronic antibody mediated rejection (cAMR) and to search for a predictive tool (biomarker). The functional analysis will help to better understand B cell-dependant mechanisms implied in T cell proliferation and better target future treatments.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

116

Start Date

2013-06-13

Completion Date

2016-12-12

Last Updated

2026-06-08

Healthy Volunteers

No

Interventions

OTHER

Presence of DSA w/ cAMR

OTHER

Presence of DSA w/o cAMR

OTHER

No DSA No cAMR

Locations (13)

CHU Amiens

Amiens, France

Chu Angers

Angers, France

CHU Brest

Brest, France

CHU CAEN

Caen, France

Chu Clermont Ferrand

Clermont-Ferrand, France

CHU Limoges

Limoges, France

APHP Hôpital Necker

Paris, France

CHU Poitiers

Poitiers, France

CHU Reims

Reims, France

CHU Rennes

Rennes, France

CHU Rouen

Rouen, France

Hôpitaux Universitaires de Strasbourg

Strasbourg, France

CHU Tours

Tours, France