Inclusion Criteria:
1. Ages eligible for study between 18 Years and 75 Years.
2. Confirmed histological diagnosis of colorectal cancer.
3. Subjects with advanced/metastatic Colorectal Cancer(CRC) who have failed to the irinotecan- ,oxaliplatin- and fluoropyrimidine-based regimens or been intolerant to irinotecan or rejected the chemotherapy.
4. Eastern Cooperative Oncology Group (ECOG) of 0 or 1.
5. Subjects must have a life expectancy of at least 12 weeks.
6. Patients with at least one evaluable lesion (evaluable disease) by the RECIST criteria.
7. Adequate renal function (creatinine ≤ 1.5 x UNL), liver function (total bilirubin ≤ 1.5 x UNL, alanine aminotransferase(ALT)\< 2.5 x UNL, aspartate aminotransferase(AST) \< 2.5 x UNL or ≤ 5 x UNL if hepatic metastasis) and leucocytes ≥ 3×10\^9, absolute neutrophil count ≥ 1.5×10\^9/L, platelets \> 80×10\^9/L, haemoglobin ≥ 9 g/dl. Electrolyte: in the normal range, or abnormal but no clinical significance (judged by the researchers), allow to give supplements to correct the electrolyte.
8. Both women of child-bearing potential and sexually active men must agree to use adequate contraception prior to study entry and for the duration of study participation and for 90 days after the conclusion of study therapy.
9. Patients who have capable to understand the procedure and methods of the study,are willing to strictly follow the protocol and sign the the informed consent.
Exclusion Criteria:
1. Previous therapy with anti-EGFR drugs.
2. Patients who are receiving other accompanying antineoplastic therapy (including antitumor treatment with traditional Chinese medicine), long-term systemic immune therapy, or hormone therapy except for physiological replacement therapy (for example, people with thyroid hypofunction receive the thyroid hormone).
3. Radiotherapy or surgery (except always diagnostic biopsy).
4. Patients with known cerebral metastasis or leptomeningeal metastasis.
5. Any other malignant tumour in the last five years, except for suitably treated in situ cervical carcinoma or basal cell carcinoma.
6. Clinically significant cardiovascular disease, such as heart failure (NYHA Ⅲ-Ⅳ), uncontrolled coronary heart disease, cardiomyopathy, cardiac arrhythmias, hypertension (\> 140/90 mmHg), myocardial infarction in the last half year, echocardiogram showed ejection fraction \< 50%.
7. Patients with any symptom of acute or subacute bowel obstruction and/or inflammatory bowel disease.
8. Patients with known active and severe infections(\> grade 2, National Cancer Institute Common Toxicity Criteria(NCI-CTC) adverse effect(AE) V. 4.03), including active tuberculosis(TB).
9. HIV infection or active hepatitis B or hepatitis C.
10. Uncontrolled diabetes (\> grade 2, NCI-CTC AE V. 4.03), severe lung disease (acute lung disease, pulmonary fibrosis that affect the lung function, and interstitial lung disease), liver failure.
11. Patients with blood coagulation dysfunction as following situation: prothrombin time (PT) ≥ 1.5 x UNL, thrombin time (TT) ≥ 1.5 x UNL, the part activated clotting time (APTT) ≥ 1.5 x UNL.
12. Patients who have blood transfusion, or use the g-csf cytokines etc in the last 10 days.
13. Known hypersensitivity to any component of pretreated product.
14. Pregnancy or breastfeeding.
15. Patients with known drug and/or alcohol abuse.
16. Patients with a clear history of neurological or psychiatric disorders, including epilepsy or dementia.
17. Patient participation in another clinical trial or receive other research drugs during the previous 4 weeks.
18. Patients with a medical or mental abnormalities unable to give informed consent.
19. Lack of legal behavior ability or limited legal behavior ability.
20. Other factors that may affect the efficacy or safety evaluation of this study assessed by researchers.
