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Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease
Sponsor: Hamilton Health Sciences Corporation
Summary
Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require dialysis. It works by blocking a hormone (aldosterone) in your body that causes high blood pressure and can damage the heart. Although spironolactone is very effective in patients that do not require dialysis, we do not know if spironolactone is effective in dialysis patients. Our research will help determine if spironolactone reduces heart failure and heart related deaths in dialysis patients. The purpose of this study is to determine if spironolactone reduces death or hospitalization for heart failure and is well tolerated in patients that require dialysis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2538
Start Date
2017-07-07
Completion Date
2025-03-14
Last Updated
2026-08-13
Healthy Volunteers
No
Conditions
Interventions
Spironolactone 25Mg Tablet
Randomized participants will receive a study supply of spironolactone 25 mg tablets. They will be instructed to take 1 tablet daily.
Placebo Oral Tablet
Randomized participants will receive a study supply of placebo tablets with no active medical ingredients. They will be instructed to take 1 tablet daily.
Locations (141)
Canberra Hospital
Garran, Australian Capital Territory, Australia
Concord Repatriation General Hospital
Concord, New South Wales, Australia
Northern Beaches Hospital
Frenchs Forest, New South Wales, Australia
Royal North Shore Hospital
Wahroonga, New South Wales, Australia
Sydney Adventist Hospital
Wahroonga, New South Wales, Australia
Sunshine Coast University Hospital
Birtinya, Queensland, Australia
Royal Brisbane Women's Hospital
Herston, Queensland, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Monash Health
Clayton, Victoria, Australia
Western Health - Sunshine Hospital
Saint Albans, Victoria, Australia
Santa Casa de Misericordia de Belo Horizonte
Santa Efigênia, Belo Horizonte, Brazil
Medical School of Botucatu of the Paulista State University - UNESP
Rubião Júnior, Botucatu, Brazil
Fundacao Pro-Rim
Boa Vista, Joinville, Brazil
Felicio Rocho Foundation - Hospital Felicio Rocho
Belo Horizonte, Minas Gerais, Brazil
Fundacao Hospitalar Sao Francisco de Assis
Belo Horizonte, Minas Gerais, Brazil
Servico Ubaense de Nefrologia Ltda
Ubá, Minas Gerais, Brazil
Sociedade Hospitalar Angelina Caron
Campina Grande do Sul, Paraná, Brazil
Instituto Pro Renal Brazil
Curitiba, Paraná, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre -ISCMPA
Bairro Santa Teresa, Porto Alegre, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Hospital Arquidiocesano Consul Carlos Reneaux
Brusque, Santa Catarina, Brazil
PROCARDIO Clinica Cardiologica
Blumenau, South Carolina, Brazil
Praxis Pesquisa Medica S/S
Santo André, São Paulo, Brazil
Santa Casa de Misericordia de Votuporanga
Votuporanga, São Paulo, Brazil
Hospital Alemao Oswaldo Cruz
Bela Vista, Brazil
Santa Casa de Misericordia de Ponta Grossa
Ponta Grossa, Brazil
Foothills Hospital
Calgary, Alberta, Canada
University of Alberta
Edmonton, Alberta, Canada
Royal Inland Hospital
Kamloops, British Colombia, Canada
Kelowna General Hospital
Kelowna, British Colombia, Canada
St. Pauls Hospital
Vancouver, British Colombia, Canada
Penticton Regional Hospital
Penticton, British Columbia, Canada
Queen Elizabeth II Health Science Centre
Halifax, Nova Scotia, Canada
Cape Breton Regional Hospital
Sydney, Nova Scotia, Canada
Health Sciences North Research Institute
Greater Sudbury, Ontario, Canada
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Queens University at Kingston General Hospital, Division of Nephrology
Kingston, Ontario, Canada
Victoria Hospital
London, Ontario, Canada
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
St. Josephs, Toronto
Toronto, Ontario, Canada
Humber River Health
Toronto, Ontario, Canada
CIUSSS Hopital Maisonneuve- Rosemont
Montreal, Quebec, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, Canada
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, Canada
The Sir Mortimer B. Davis Jewish General Hospital
Montreal, Quebec, Canada
CHU de Quebec L'Hotel-Dieu de Quebec
Québec, Quebec, Canada
Peking University First Hospital
Beijing, Beijing Municipality, China
Peking University Peoples Hospital
Beijing, Beijing Municipality, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
The First Affiliated Hospital of Baotou Medical College
Baotou, China
Beijing Miyun District Hospital
Beijing, China
Beijing Tongren Hospital, Capital Medical University
Beijing, China
Emergency General Hospital
Beijing, China
Faw General Hospital of Jilin Province
Changchun, China
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
Enshi, China
Huai'an First Peoples Hospital
Huai'an, China
The First Hospital of Kunming
Kunming, China
Gansu Baoshihua Hospital
Lanzhou, China
Yichuan County Traditional Chinese Medicine Hospital
Luoyang, China
Shanghai Tongji Hospital
Shanghai, China
Shanxi Provincial Peoples Hospital
Shanxi, China
Shuyang County Hospital of Traditional Chinese Medicine
Suqian, China
Sihong County Fenjinting Hospital
Suqian, China
Tianjin Fifth Central Hospital
Tianjin, China
Tianjin Third Central Hospital
Tianjin, China
Tongiao City Hospital
Tongliao, China
Xinxiang First Peoples Hospital
Xinxiang, China
General Hospital of Xuzhou Mining Group
Xuzhou, China
Peoples Hospital of Yuxi City
Yuxi, China
Peoples Hospital of Zhongwei
Zhongwei, China
Clinefnorte CIA Ltda
Quito, Pichincha, Ecuador
Nefromedic SA
Quito, Pichincha, Ecuador
Madras Medical College Chennai
Park Town, Chennai, India
Narayana Hrudayalaya Limited
Bangalore, Karnataka, India
Fortis Hospitals
Bengaluru, Karnataka, India
K S Hegde Medical Academy
Mangaluru, Karnataka, India
Nanjappa Hospitals Shimoga
Shimoga, Karnataka, India
AsterMedCity
Kochi, Kerala, India
Caritas Hospital
Kottayam, Kerala, India
AIMS Hospital Mumbai
Dombivali, Maharashtra, India
National Health and Education Society
Mumbai, Maharashtra, India
Ashirwad Hospital Mumbai
Mumbai, Maharashtra, India
Dhadiwal Hospital
Nashik, Maharashtra, India
ACE Hospital Une
Pune, Maharashtra, India
Aditya Birla Hospital
Pune, Maharashtra, India
Vijaya Hospital
Chennai, Tamil Nadu, India
Apollo Hospitals
Chennai, Tamil Nadu, India
Nizams Institute of Medical Sciences
Hyderabad, Telangana, India
Osmania General Hospital
Hyderabad, Telegana, India
Government Rajaji Hospital, Madurai
Madurai, India
Father Muller Medical College
Mangalore, India
Seven Star Hospital
Nagpur, India
Hospital Sultanah Aminah, Johor Bahru
Johor Bahru, Johor, Malaysia
Hospital Pakar Sultanah Fatimah
Muar town, Johor, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, Malaysia
University Malaya Medical Centre (UMMC)
Kuala Lumpur, Kuala Lumpur, Malaysia
Hospital Sultanah Nur Zahirah Kuala Terengganu
Kuala Terengganu, Kuala Terengganu, Malaysia
Hospital Taiping
Taiping, Perak, Malaysia
Hospital Pulau Pinang
George Town, Pulau Pinang, Malaysia