Clinical Research Directory

Inclusion Criteria: * Histologically confirmed advanced (FIGO stage III or IV) invasive epithelial ovarian cancer, primary peritoneal cancer, or fallopian-tube cancer. Pleural cytology has to be performed in patients with pleural effusion. * Initial intervention : debulking surgery or diagnostic surgery in the 3 weeks before inclusion * Age ≥18 and \< 75 years old. * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 before surgery (ECOG ≤ 1 and Lee score \< 6 in patients \> 70 years old). * Adequate blood count (test realized in the past 14 days before inclusion) : neutrophils \> 1500/mm3, platelets \> 150 000/mm3. * Creatinine clearance MDRD ≥ 60 mL/min * Registration in a national health care system (CMU included). * Signed and dated informed consent. Exclusion Criteria: * FIGO stage IV extra-abdominal disease, with the exception of lymph nodes and pleural invasion. * Patient having received previous chemotherapy for ovarian cancer. * Left ventricular ejection fraction \< 50% before chemotherapy initiation * Other invasive cancer in the past 5 years (baso- and spinocellular cutaneous carcinoma with complete resection are accepted) * Concomitant administration of prophylactic phenytoin or live attenuated viral vaccines such as yellow fever vaccine, * Patients with known hypersensitivity to any component of study drug * Patients without motivation or capacity to respect study requirements and constraints * Pregnancy or breast feeding women