Clinical Research Directory

Inclusion Criteria: * Personal history of hereditary retinoblastoma (i.e., familial history of retinoblastoma, or bilateral retinoblastoma, or unilateral multifocal retinoblastoma, or identified germline RB1 mutation or 13q deletion) * External beam radiation therapy (EBRT) used for retinoblastoma treatment * Age at inclusion greater or equal to 7 years old. * Time period between the end of EBRT and inclusion date of 5 years or more * Written informed consent signed by patient (or legal representative) Exclusion Criteria: * Personal history of non-familial unilateral unifocal retinoblastoma without RB1 germline mutation. * Personal history of second primary neoplasm occurring within radiation fields * Contraindication for MRI (pacemaker, intraocular metallic foreign body, defibrillators or other implanted electronic devices, intracranial ferro-magnetic clips) or associated conditions preventing from MR examination (intraocular prostheses and implants are not a contraindication for MRI; orthodontic metallic devices are not a contraindication but might decrease the image quality and should be removed, if possible) * Patients unable to comply with follow-up study requirements, for any geographical, social or psychological reason