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Lysine-specific Demethylase 1 and Salt-sensitivity in Humans
Sponsor: Brigham and Women's Hospital
Summary
The purpose of this study is to investigate the role dietary salt plays in epigenetic regulation of blood pressure, focusing on the salt-sensitive regulatory enzyme Lysine-specific demethylase 1.
Key Details
Gender
All
Age Range
25 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2017-01-02
Completion Date
2026-06-01
Last Updated
2025-11-21
Healthy Volunteers
Yes
Conditions
Interventions
Aldosterone response to AngII LS
Change in aldosterone from baseline to after Ang II infusion on a LS diet
Renal blood flow response to salt
Change in renal blood flow: High salt to low salt diet
Vascular Stiffness
Change in vascular stiffness, baseline compared to AngII
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States