Clinical Research Directory

Inclusion Criteria: * Male or female * 18 years of age or older * Current evidence of HBV chronic infection (with or without cirrhosis) as indicated by detection of HBsAg and/or Hepatitis B DNA (Subjects on current nucleoside therapy may have no detectable Hep B DNA) * If child bearing age, using contraception (barrier method, IUD or oral contraception) * Able to provide written informed consent * Willing and able to comply with the protocol for the duration of the study. Exclusion Criteria: * Positive for antibody to hepatitis B core antigen (anti-HBc) IgM with negative results for the rest of the HBV markers, indicating acute infection, * Positive for anti-delta virus, or anti-hepatitis C virus or HIV * Childs Pugh Score for Cirrhosis Mortality of Child grade B or greater * Liver transaminases greater than 5 times the upper limit of normal * History of severe allergic reaction to hepatitis B vaccine. * Pregnancy or female of child-bearing age not using effective method of contraception. * Presence of any other organ-specific disease that in the opinion of the investigator may result in risk to the subject from involvement in the study * Current alcohol or drug abuse that in the opinion of the investigator may result in non-compliance. * Participation in another clinical trial with an investigational agent within 30 days preceding initiation of treatment