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Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans
Sponsor: The Cleveland Clinic
Summary
The investigators are interested in learning more about choline, a nutrient required by the body. The body does make some choline, but it does not make enough to support health and the rest must be acquired through diet. Eggs, and especially egg yolks, are a major dietary source of choline. Choline can also be given as a dietary supplement. Ingestion of choline supplements has been linked to an increased concentration of a compound called TMAO (trimethylamine N-oxide). Elevated TMAO levels have been linked to higher heart disease risk. With this study, the investigators hope to learn whether there is a difference in the way your body responds to the ingestion of a choline supplement versus the choline found within eggs.
Official title: Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans (EGGS)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
86
Start Date
2016-09-02
Completion Date
2020-09-03
Last Updated
2026-07-13
Healthy Volunteers
Yes
Conditions
Interventions
Choline Bitartrate
500mg choline bitartrate tablets
Pre-cooked, pre-peeled whole hardboiled eggs
Obtained from a commercial source.
Egg whites from pre-cooked, pre-peeled hardboiled eggs
Egg whites from pre-cooked, pre-peeled hardboiled eggs. The yolks are removed and discarded.
Phosphatidylcholine capsules
420 mg phosphatidylcholine capsules obtained from a commercial source.
Locations (1)
Cleveland Clinic Foundation
Cleveland, Ohio, United States