Clinical Research Directory

* SUBJECT INCLUSION CRITERIA (SCD): 1. Sickle cell disease (all genotypes) with a diagnosis of acute sickle cell pain not related to other cause (if the patient also presents with any other sickle related complication alongside acute sickle pain, including not limited to acute chest syndrome, renal dysfunction, liver dysfunction, stroke and priapism can also be included in the study) 2. Between 18 and 80 years of age 3. Ability to provide informed written consent SUBJECT EXCLUSION CRITERIA (SCD): 1. \<18 years of age 2. Pregnancy 3. Chronic inflammatory condition (e.g. SLE, Rheumatoid arthritis or any other infectious process leading to chronic inflammation) 4. Failed stem cell transplantation for SCD 5. On active treatment with cytotoxic or immunosuppressive therapy INCLUSION CRITERIA FOR HEALTHY CONTROL SUBJECTS: 1. Between 18 and 80 years of age 2. African, of African descent 3. Ability to provide informed written consent EXCLUSION CRITERIA FOR HEALTHY CONTROL SUBJECTS: 1. Pregnancy 2. Diagnosis of with any of the following chronic disease or conditions: 1. Sickle cell disease or sickle cell trait 2. Uncontrolled high blood pressure (systolic blood pressure must not be greater than 160 mmHg or diastolic pressure greater than 90 mmHg 3. Uncontrolled diabetes (must not have both a documented history of diabetes and random blood glucose of greater than 200 mg/dL) 4. History of coronary artery disease 5. History of congestive heart failure 6. Chronic kidney disease (serum creatinine must not be greater than 2mg/dL)