Clinical Research Directory

Inclusion Criteria: 1. Subject is a candidate for primary total knee arthroplasty due to degenerative joint disease 2. Subject is willing to sign and date an EC-approved consent form 3. Subject is male or female between the ages of 18 and 75 years of age 4. Subject plans to be available through ten (10) years post-operative follow-up 5. Subject agrees to follow the study protocol Exclusion Criteria: 1. Subject would receive the ANTHEM™ Total Knee System on the affected knee as a revision for a previously failed total or unicondylar knee arthroplasty 2. Subject received TKA on the contralateral knee as a revision for a previously failed total or unicondylar knee arthroplasty 3. Subject has a history of patellar fracture, patellectomy, patello-femoral instability 4. Subject has inflammatory arthritis 5. Subject possesses a contralateral or ipsilateral revision hip arthroplasty 6. Subject has ipsilateral hip arthritis resulting in flexion contracture 7. Subject has one or more of the following arthroplasties that are not fully healed and well-functioning, as determined by the Investigator: * Ipsilateral or contralateral primary total hip arthroplasty or hip resurfacing arthroplasty * Contralateral primary total knee or unicondylar knee arthroplasty 8. Subject has an active infection or sepsis (treated or untreated) 9. Subject has presence of malignant tumor, either primary or metastatic, or benign tumor on leg with the knee to be treated 10. Subject has conditions that may interfere with the TKA survival or outcome (e.g. Paget's or Charcot's disease, vascular insufficiency, muscular atrophy, uncontrolled diabetes mellitus i.e. not under treatment with oral/injectable medications to control blood glucose levels, fibromyalgia, moderate to severe renal insufficiency or neuromuscular disease) 11. Subject has a chronic, contralateral lower extremity condition causing abnormal ambulation, which is not related to the knee (e.g. ankle fusion, ankle arthroplasty, previous hip fracture). 12. Subject is pregnant or plans to become pregnant during the study 13. Subject has an emotional or neurological condition that would pre-empt their ability or willingness to participate in the study, including mental illness, mental retardation, drug or alcohol abuse 14. Subject has a BMI\>40 15. Subject is enrolled in another investigational drug, biologic, or device study 16. Subject is facing current or impending incarceration 17. Subject has an inadequate bone stock to support the device which would make the procedure unjustifiable, including but not limited to: severe osteopenia/osteoporosis or family history of severe osteoporosis/osteopenia