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Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function
Sponsor: Nantes University Hospital
Summary
Each year, only one third of patients registered on the waiting list receive a kidney transplant. Numerous paths are being explored with the aim of reversing this shortage. The first is to increase the number of organs by developing harvesting from donors in a state of brain-death (BD) termed "expanded criteria donors" or from patients deceased from circulatory arrest. Another fundamental factor is to insure the success of the transplant by limiting the dysfunction of donor kidneys, marked by a delayed graft function (DFG). The development of techniques to insure correct perfusion of harvested organs, and the optimization of reanimation and intensive care of brain-dead donors constitute important factors in DGF reduction. Therapeutic Hypothermia could to be an attractive care strategy for BD patients.
Official title: Impact of Therapeutic Hypothermia in Expanded Criteria Brain-dead Donors on Kidney-graft Function in the Kidney-transplant Recipients: Multicenter Randomized Controlled Trial" HYPOREME
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
532
Start Date
2017-11-08
Completion Date
2022-03-21
Last Updated
2026-09-14
Healthy Volunteers
No
Interventions
Procedure control: normothermia
Temperature will be maintained between 36.5° and 37.5°C in the control group. In case of temperature superior to 37.5°C or inferior to 36.5°C, a pharmaceutical treatment and/or active cooling or warming will be introduce to maintain temperature between the range of 36.5 - 37.5°C.
Procedure active
Therapeutic hypothermia ie targeted controlled temperature between 34° and 35°C will be induced in the active group. Usual method of controlled temperature will be used in ICU: internal active method or external active method.
Locations (54)
CHU Amiens-Picardie
Amiens, France
CHU d'Angers
Angers, France
CH Angouleme
Angoulême, France
CH Avignon
Avignon, France
CH de Blois
Blois, France
CHU de Bordeaux
Bordeaux, France
CH Bourges
Bourges, France
CHU Brest
Brest, France
CHU Caen
Caen, France
Ch Cholet
Cholet, France
Chu Clermont Ferrand
Clermont-Ferrand, France
Hopital Henri Mondor
Créteil, France
CHU de Dijon
Dijon, France
CH de Dreux
Dreux, France
CHU Grenoble
Grenoble, France
CH Marne la Vallée (GHEF)
Jossigny, France
CH La Roche sur Yon
La Roche-sur-Yon, France
CH La Rochelle
La Rochelle, France
CH Laval
Laval, France
Hopital Bicetre
Le Kremlin-Bicêtre, France
CH Le Mans
Le Mans, France
CHRU Lille
Lille, France
CHU Limoges
Limoges, France
CH Lorient
Lorient, France
CHU de Lyon
Lyon, France
Hopital de la Conception
Marseille, France
Hopital de la Timone
Marseille, France
CH de Meaux (GHEF)
Meaux, France
CHU Montpellier
Montpellier, France
CH Morlaix
Morlaix, France
Nantes University Hospital
Nantes, France
CHU Nice
Nice, France
CH Orléans
Orléans, France
Hopital Saint Louis
Paris, France
Hopital de la Pitié Salpetriere
Paris, France
Hopital Necker
Paris, France
CHU Tenon
Paris, France
CHU Poitiers
Poitiers, France
CH Annecy Genevois
Pringy, France
CH Cornouaille
Quimper, France
CHU Reims
Reims, France
CHU Rennes
Rennes, France
CHU Rouen
Rouen, France
CH Saint Brieuc
Saint-Brieuc, France
CHRU Saint-Etienne
Saint-Etienne, France
CH Saint Nazaire
Saint-Nazaire, France
CH Saintes
Saintes, France
CH Saint Malo
St-Malo, France
CHU Strasbourg
Strasbourg, France
CHU Foch
Suresnes, France
CHU Toulouse
Toulouse, France
CHU Tours
Tours, France
CHRU Nancy
Vandœuvre-lès-Nancy, France
CH Vannes
Vannes, France