Clinical Research Directory

Inclusion Criteria: 1. adult patients (≥18 years old), 2. in a medical or surgical ICU at Vanderbilt University Medical Center or The Ohio State University Medical Center, and 3. are being treated for respiratory failure or shock. Exclusion Criteria: 1. Rapidly resolving organ failure criteria, indicated by planned immediate discontinuation of mechanical ventilation, NIPPV, and/or vasopressors at the time of screening for study enrollment, such that the patient will no longer meet inclusion criteria. 2. Cumulative hospital days (ICU plus non-ICU) of five or greater in the last 30 days prior to meeting all inclusion criteria. 3. Inability to live independently at baseline due to acquired or congenital disabling, physical, cognitive or mental health disorder requiring institutionalization (e.g., nursing home, skilled nursing facility, group home, long-term acute care hospital, rehab facility) or any patient who resides outside an institution with an inability to walk without the assistance of another person (e.g., patients with quadriplegia, paraplegia, double amputees, those with residual paralysis from stroke). 4. Acute or subacute severe neurologic (e.g., stroke anoxic injury, spinal cord injury) that is expected to prevent the patient from living independently after hospital discharge. 5. Body mass index \>50 6. Active substance abuse or psychotic disorder (e.g., schizophrenia or schizo-affective disorder), recent (within the past 6 months) serious suicidal gesture necessitating hospitalization 7. Blindness, deafness, or inability to understand English that will preclude follow-up evaluation. Patients with laryngectomies and those with hearing impairments are eligible for enrollment if their medical condition permits them to communicate with research staff. 8. Expected death within 24 hours of enrollment or lack of commitment to aggressive treatment by family or the medical team (e.g., likely to withdraw life support measures within 24 hours of screening). 9. Prisoners 10. Patients who live further than 200 miles from an enrolling center and who do not regularly visit the area. 11. Patients who are homeless and have no secondary contact person available 12. Current enrollment in a study that does not allow co-enrollment 13. Inability to obtain informed consent from the patient or an authorized representative within 72 hours of meeting all inclusion criteria for the following reasons: 1. Attending physician refusal 2. Patient and/or surrogate refusal 3. 72-hour period of eligibility was exceeded before the patient was screened 4. Patient unable to consent and no surrogate available within 72 hours of meeting all inclusion criteria 14. Confirmed or suspected COVID-19 per local guidelines at the time of screen.