Clinical Research Directory

Inclusion Criteria: * Patient with grade 1 or 2 invasive ductal adenocarcinoma or ductal carcinoma in situ, regardless of grade (found on mammography by an outbreak of Single microcalcification with a diameter not exceeding 2 cm or a tumor opacity \<2 cm), * Patient aged 60 years or older (patients 60 years of age in the year may be included); * Unilateral adenocarcinoma, unifocal, positive HR, non-overexpressed HER-2 - T1 N0 radio-clinical , Operable patient with breast volume compatible with conservative surgery, * Patients who have been made aware of the information sheet and have given their written signed informed consent. * Patients benefitting from social health insurance coverage. Exclusion Criteria: * Age less than 60 years * Patient with grade 3 invasive breast carcinoma * Patient with lymphatic invasion / peri-nerve involvement / vascular emboli * Metastatic patient * Multifocal and / or bilateral tumor * N1 proved by ultrasound guided * Patient with psychological and / or psychiatric disorders * Vulnerable patient: a person deprived of liberty by an administrative or judicial decision, a major person who is the object of a legal protection measure or is unable to express his / her consent