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A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis
Sponsor: Memorial Sloan Kettering Cancer Center
Summary
The purpose of this study is to try to understand how histopcytosis can cause symptoms or problems in the brain. The tests being done in the study will look at memory and thinking as well as brain function via MRI scan.
Official title: A Clinical, Structural, and Functional Neuroimaging Study of Cognition in Adults With Erdheim-Chester Disease, Langerhans Cell Histiocytosis, Rosai-Dorfman Disease, and Other Histiocytoses
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
13
Start Date
2017-04-07
Completion Date
2026-04
Last Updated
2025-05-02
Healthy Volunteers
No
Conditions
Interventions
Trail Making Test, Parts A & B
Part A is a timed measure of visual scanning and graphomotor speed. Part B is a timed measure of cognitive flexibility.
Brief Test of Attention
Assesses auditory working memory
Symbol Span
Assesses visual working memory
Controlled Oral Word Association Test
The COWA timed test of phonemic verbal fluency. It requires the subject to generate as many words as possible, beginning with a given letter of the alphabet (i.e., F, A, and S).
The Hopkins Verbal Learning Test-Revised
HVLT-R is a test of verbal learning and memory. Scores obtained are the total number of words.
Brief Visuospatial Memory Test-Revised
The BVMT-R is a test of visuospatial learning and memory.
Hospital Anxiety and Depression Scale
The HADS is a brief assessment validated in many cancer populations.
McGill Quality of Life Scale
This is a questionnaire that is a validated 17-item QOL instrument validated for ill patients and in the particular context of the ancer.
MR Brain Imaging
Standard of care brain MR imaging includes high-resolution 3D T1-weighted images in the axial plane. The axial T1-weighted images will be isotropic with a typical matrix size of 256 x 256, 256 mm field-of-view (FOV) and 1 mm slice thickness covering the whole brain.
Resting state functional MRI
Scanning will be performed on a 3 Tesla General Electric scanner (Optima 750W) with a GEM HNU 24-channel head coil. rsFMRI matching the FLAIR and T1 post-contrast images will be obtained. For resting state fMRI, T2\*-weighted images will be acquired with a single-shot gradient echo echo-planar imaging (EPI) sequence in the axial orientation (TR = 2500 ms, TE = 30 ms, FA = 80°, slice thickness = 4 mm, FOV= 240mm2, matrix=64×64) covering whole brain. For the resting state fMRI portion of the scan, patients will be instructed by the technologist or research staff to leave eyes open, focus on looking at a crosshair, and not think about anything during the scan.
Functional Assessment of Cancer Therapy Cognitive Scale (FACT-Cog)
This is a validated 37-item QOL instrument for cancer patients with cognitive complaints. The measures consist of FACT-Cog total, perceived cognitive impairments, perceived cognitive abilities, and impact on quality of life.
Locations (4)
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States
Memorial Sloan Kettering Cancer Center @ Suffolk
Commack, New York, United States
Memorial Sloan Kettering Westchester
Harrison, New York, United States