Clinical Research Directory

Inclusion Criteria: * Female and male individuals referred to the Toulouse Frailty Clinic with an objective memory impairment (CDR=0.5 or CDR=1) * Age ≥ 70 years * At least 1 Fried-criterion * Informed consent signed by the patient * Having an informant accompanying or available by phone * Individuals affiliated to a healthcare scheme. * \- Willing to be informed in case of a new pathology discovered through medical examination Extension study (Cog-Frail Plus): * COGFRAIL study participants still included in the study and completing their last visit (M 24) * Having a family member or legal representant to sign the consent form if MMSE score \<20 at the last visit (M24) Exclusion Criteria: * Individuals presenting severe visual or auditory difficulties which may interfere with the completion of neuropsychological and functional assessments. * Presence of any pathology or severe clinical or psychological condition that, according to the investigator, might interfere with study results or may expose the participants to additional risks. * Individuals who are robust according to the Fried criteria (0 criteria) * Individuals who are dependent (Activities of Daily Living (ADL) \<4) * Individuals who have a major deterioration in global cognitive function (Mini Mental State Examination (MMSE) \<20) * Subjects deprived of their liberty by administrative or judicial decision, or under guardianship or admitted to a healthcare or social institution (subjects in non-assisted living facilities could be recruited); Exclusion criteria for MRI scanning : * Claustrophobia * Trauma or surgery which may have left ferromagnetic material in the body, including pacemakers * History of neurosurgery or aneurism Extension study (Cog-Frail Plus): * Presence of any severe pathology that, according to the investigator, might interfere with study results or may expose the participants to additional risks. * Subjects deprived of their liberty by administrative or judicial decision, or under guardianship