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The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation
Sponsor: Herlev and Gentofte Hospital
Summary
No randomized head-to-head comparison between the individual Non-vitamin K Antagonist Oral Anticoagulants (NOAC) exists. The DANNOAC-AF study is a nationwide cluster randomized cross-over study comparing efficacy and safety of the four NOACs, edoxaban, apixaban, rivaroxaban and dabigatran for oral anticoagulation in atrial fibrillation and atrial flutter across Danish hospitals and cardiology clinics.
Official title: The Danish Non-vitamin K Antagonist Oral Anticoagulation Study. A Cluster Randomized Study Comparing Safety and Efficacy of Edoxaban, Apixaban, Rivaroxaban and Dabigatran for Oral Anticoagulation in Atrial Fibrillation (DANNOAC-AF).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
11000
Start Date
2023-04-01
Completion Date
2027-10-30
Last Updated
2025-05-18
Healthy Volunteers
No
Conditions
Interventions
Dabigatran Etexilate Oral Capsule
After cluster randomization, the cluster will use dabigatran to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.
Rivaroxaban Oral Tablet
After cluster randomization, the cluster will use rivaroxaban to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.
Edoxaban Oral Tablet
After cluster randomization, the cluster will use edoxaban to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.
Apixaban Oral Tablet
After cluster randomization, the cluster will use apixaban to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.
Locations (38)
Hjerteklinik Nordjylland
Aalborg, Denmark
Aarhus University Hospital
Aarhus, Denmark
Hjertelægerne i Ballerup
Ballerup Municipality, Denmark
Hjertelæge Christian Lange
Copenhagen, Denmark
Bispebjerg Hospital - Department of Geriatrics
Copenhagen, Denmark
Hjerteklinikken Amaliegade
Copenhagen, Denmark
Hjerteklinikken ved Speciallæge Anders Galløe
Copenhagen, Denmark
Bispebjerg Hospital - Department of Neurology
Copenhagen NV, Denmark
Amager Hospital
Copenhagen S, Denmark
Hjerteklinik Østerbro I/S
Copenhagen Ø, Denmark
Rigshospitalet
Copenhagen Ø, Denmark
Esbjerg Hospital
Esbjerg, Denmark
Bispebjerg and Frederiksberg Hospital - Department of Cardiology
Frederiksberg, Denmark
Frederiksberg Hjerteklinik
Frederiksberg, Denmark
Nordsjællands Hospital - Frederiksund
Frederikssund, Denmark
Gentofte Hospital
Gentofte Municipality, Denmark
Glostrup Hospital - Department of Emergency Medicine
Glostrup Municipality, Denmark
Glostrup Hospital - Department of Medicine / Cardiology
Glostrup Municipality, Denmark
Glostrup Hospital - Department of Neurology
Glostrup Municipality, Denmark
Herlev-Gentofte Hospital - Department of Medicine
Herlev, Denmark
Hjertelægerne i Hillerød
Hillerød, Denmark
Nordsjællands Hospital - Hillerød
Hillerød, Denmark
Hjørring Hospital
Hjørring, Denmark
Holbæk Hospital
Holbæk, Denmark
Speciallæge Michael Dilou Jacobsen
Holte, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Næstved Hospital
Næstved, Denmark
Odense University Hospital - Department of Cardiology
Odense, Denmark
Odense University Hospital - Department of Emergency Medicine
Odense, Denmark
Odense University Hospital - Department of Geriatrics
Odense, Denmark
Odense University Hospital - Department of Neurology
Odense, Denmark
Zealand University Hospital - Department of Neurology
Roskilde, Denmark
Zealand University Hospital Roskilde - Department of Cardiology
Roskilde, Denmark
Bornholms Hospital
Rønne, Denmark
Slagelse Hospital
Slagelse, Denmark
Odense University Hospital Svendborg
Svendborg, Denmark
Klinik Hjertesund
Taastrup, Denmark
Vejle Hospital
Vejle, Denmark