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Role of Microglia in the Pathogenesis of Progressive Multiple Sclerosis
Sponsor: Turku University Hospital
Summary
Our aim is to evaluate whether translocator binding protein (TSPO)-imaging correlates to Expanded Disability Status Scale (EDSS) and other disease progression-related clinical and paraclinical parameters in a homogenous cohort of 40-50-year old MS-patients, who are at risk of progression. The A2A-AR expression in this cohort will also be studied using the adenosine A2A-receptor (A2A-AR)-binding radioligand 11C-TMSX. The study cohort will also form the basis for a later follow-up study, which will be performed to evaluate the prognostic value of baseline TSPO-imaging in terms of disease progression. TSPO-imaging could thus be used as an imaging biomarker to help identifying patients to therapeutically prevent progression of MS. At the 5 year time point synaptic density will be evaluated using 11C-UCB-J radioligand and PET imaging.
Key Details
Gender
All
Age Range
40 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
35
Start Date
2016-04
Completion Date
2026-12
Last Updated
2025-09-22
Healthy Volunteers
Yes
Conditions
Locations (1)
Turku PET Centre
Turku, Southwest Finland, Finland