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Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia
Sponsor: Basilea Pharmaceutica
Summary
The purpose of this study was to compare the efficacy and safety of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated Staphylococcus aureus bacteremia (SAB).
Official title: A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
390
Start Date
2018-08-26
Completion Date
2022-03-11
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
Ceftobiprole medocaril
Ceftobiprole 500 mg (as 667 mg ceftobiprole medocaril) as a 2 h infusion
Daptomycin
Daptomycin 6 mg/kg (up to 10 mg/kg based on institutional standards) as a 0.5 h infusion, with or without aztreonam
Locations (60)
eStudy Site - Chula Vista - PPDS
Chula Vista, California, United States
Triple O Medical Services Inc
West Palm Beach, Florida, United States
Mercury Street Medical Group
Butte, Montana, United States
eStudy Site - Las Vegas - PPDS
Las Vegas, Nevada, United States
Remington Davis Inc.
Columbus, Ohio, United States
Central Hospital de San Isidro Melchor Posse
Buenos Aires, Argentina
Medical Institute Platense SA
La Plata, Argentina
British Sanatorium SA
Rosario, Argentina
University Multiprofile Hospital for Active Treatment "Eurohospital Plovdiv", Plovdiv, Intensive Care Clinic
Plovdiv, Bulgaria
University Multiprofile Hospital for Active Treatment 'Kanev', Ruse, Department of General, Purulent-Septic, Pediatric and One Day Surgery
Rousse, Bulgaria
Multiprofile Hospital for Active Treatment "Dr. Ivan Seliminski", Sliven, Anesthesiology and Intensive Care Department
Sliven, Bulgaria
University Multiprofile Hospital for Active Treatment and Emergency Medicine "N.I. Pirogov", Sofia, Clinic of Purulent-Septic Surgery
Sofia, Bulgaria
De La Costa Clinic Ltd.
Barranquilla, Colombia
JSC Rustavi Central Hospital
Rustavi, Georgia
LTD High Technology Medical Center University Clinic
Tbilisi, Georgia
LTD Academician G. Chapidze Emergency Cardiology Center
Tbilisi, Georgia
LTD Institute of Clinical Cardiology
Tbilisi, Georgia
LTD Academician Vakhtang Bochorishvili Clinic
Tbilisi, Georgia
LTD Central University Clinic After Academic N. Kipshidze
Tbilisi, Georgia
LTD N 5 Clinikal Hospital
Tbilisi, Georgia
University Hospital Regensburg, Department of Infectious Diseases
Regensburg, Germany
"LAIKO" General Hospital, 1st Department of Internal Medicine
Athens, Greece
Bnai Zion Medical Center
Haifa, Israel
The Baruch Padeh Medical Center
Poria Illit, Israel
Chaim Sheba Medical Center
Ramat Gan, Israel
Sieff Medical Center
Safed, Israel
Sourasky Medical Center
Tel Aviv, Israel
IRCCS-University Hospital San Martino-IST, Infectious Diseases Division
Genoa, Italy
University of Milan-Bicocca- S.Gerardo Hospital
Monza, Italy
Giuliano Isontina University Health Authority
Trieste, Italy
Central Friuli University Healthcare Company
Udine, Italy
Fray Antonio Alcalde Guadalajara Civil Hospital
Guadalajara, Mexico
Dr. Jose Eleuterio Gonzalez Monterrey University Hospital
Monterrey, Mexico
INDICASAT SMO / Santo Tomas Hospital, Investigation Department
Panama City, Panama
St. Joseph Belgorod Regional Clinical Hospital
Belgorod, Russia
Vinogradov Moscow Municipal Hospital, Department of Surgery #14
Moscow, Russia
N.I. Pirogov City Clinical Hospital #1
Moscow, Russia
Federal State Budget Institution "Central Clinical Hospital with Polyclinic" under the Presidential Executive Office of Russian Federation
Moscow, Russia
L.A. Vorokhobov City Clinical Hospital #67
Moscow, Russia
City Hospital #33
Nizhny Novgorod, Russia
Pyatigorsk City Clinical Hospital
Pyatigorsk, Russia
Regional Clinical Hospital
Yaroslavl, Russia
Zvezdara University Medical Center, Clinic of Internal Diseases, Clinical Department of Nephrology and Metabolic Disorders with Dialysis "Prof. dr Vasilije Jovanovic"
Belgrade, Serbia
Clinical Center Kragujevac, Center for Anesthesia and Reanimation
Kragujevac, Serbia
Worthwhile Clinical Trials, Lakeview Hospital
Benoni, South Africa
Mediclinic Victoria - Practice of R Moodley and MI Sarwan
Tongaat, South Africa
Hospital del Mar, Department of Intensive Care
Barcelona, Spain
University Hospital de Elche, Infectious Diseases Unit
Elche, Spain
General University Hospital Gregorio Maranon, Infectious Diseases / Internal Medicine
Madrid, Spain
University Hospital Ramon y Cajal, Department of Infectious Diseases
Madrid, Spain
University Hospital Mutua de Terrassa, Unit of Infectious Diseases
Terrassa, Spain
Istanbul Kartal Kosuyolu Yuksek Ihtisas Training and Research Hospital
Istanbul, Turkey (Türkiye)
Ondokuz Mayis University School of Medicine, Department of Infectious Diseases
Samsun, Turkey (Türkiye)
Dnipropetrovsk I.I. Mechnykov Regional Clinical Hospital
Dnipro, Ukraine
Dnipropetrovsk City Multispecialty Clinical Hospital #4
Dnipro, Ukraine
Ivano-Frankivsk Regional Clinical Hospital
Ivano-Frankivsk, Ukraine
V.T. Zaitsev Institute of General and Emergency Surgery
Kharkiv, Ukraine
Public Non-Profit Enterprise: O.O. Shalimov City Clinical Hospital #2 under Kharkiv City Council
Kharkiv, Ukraine
Communal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital named after N.I. Pirogov Vinnytsia Regional Council"
Vinnytsia, Ukraine
City Clinical Hospital #3
Zaporizhzhya, Ukraine