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Combined Application of Remote and Intra-Coronary Ischemic Conditioning in Acute Myocardial Infarction
Sponsor: Hospices Civils de Lyon
Summary
Infarct size is a major determinant of prognosis after AMI. Evidence indicates that the combination of intracoronary ischemic conditioning (ICIC) and remote ischemic conditioning (RIC) can significantly reduce infarct size in STEMI patients. Whether the combination of these two interventions may improve clinical outcome after STEMI remains unknown. The objective of the present study is to determine whether combination of ICIC and RIC can improve STEMI patients clinical outcome at 6 months.
Official title: Combined Application of Remote and Intra-Coronary Ischemic Conditioning in Acute Myocardial Infarction: A Multicenter, Randomized, Controlled Clinical Trial (CARIOCA Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
750
Start Date
2018-04-12
Completion Date
2023-10-03
Last Updated
2026-05-08
Healthy Volunteers
No
Conditions
Interventions
Remote ischemic conditioning and intracoronary ischemic conditioning
RIC: Four cycles of \[5 min brachial cuff inflation at 200 mmHg followed by 5 min of cuff deflation\] started as soon as possible prior to PCI reperfusion. At least one full cycle (inflation + deflation) has to be completed before PCI reperfusion. ICIC: Four cycles of \[1 min balloon inflation followed by 1 min balloon deflation\] started as soon as possible after reopening of the culprit coronary artery (maximum within 3 minutes after reflow). The balloon will be placed carefully above the culprit lesion so as to minimize potential micro-embolization.
Patients with no remote ischemic conditioning and no intracoronary ischemic conditioning
Brachial cuff is positioned during 40 minutes but not inflated. No intracoronary balloon inflation.
Locations (4)
Algemeen Ziekenhuis Sint Jan
Bruges, Belgium
CHU de Charleroi
Charleroi, Belgium
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
Hopital Louis Pradel
Bron, France