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CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)
Sponsor: KK Women's and Children's Hospital
Summary
Postnatal depression affects about 10-15% of women after childbirth. Approximately 3-5% of women experience a moderate-to-severe depression that requires medical attention. This study aims to investigate the implication of pain relief choice in reducing the postnatal depression of women who deliver their babies.
Official title: Comparison of the Role of Epidural Analgesia Versus Non-epidural Analgesia in Postnatal Depression and Persistent Pain Development: a Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
21 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
881
Start Date
2017-06-15
Completion Date
2026-12-31
Last Updated
2025-04-18
Healthy Volunteers
No
Interventions
Epidural delivery system
Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.
Entonox
Entonox will be given upon request in non-epidural group.
Meperidine
Intramuscular pethidine (75mg/1.5ml) will be given upon request in non-epidural group.
Ultiva
Intravenous patient controlled remifentanil (20-40mcg/ml) is only given when the patient rejects or cannot receive pethidine and entonox in non-epidural group..
Fentanyl
Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.
Ropivacaine
Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.
Locations (1)
KK Women's and Children's Hospital
Singapore, Singapore