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Li-Fraumeni Syndrome Imaging Study
Sponsor: The Hospital for Sick Children
Summary
Li-Fraumeni Syndrome (LFS) is a cancer predisposition disorder in which most affected individuals develop cancer during their lifetime. The majority of LFS patients carry a mutation in a gene called TP53, whose normal function is to control cell growth and prevent cells with damaged DNA from becoming cancerous. There is currently no way to determine when, where or what type of tumour will develop. This project will use novel techniques utilizing magnetic resonance imaging (MRI) to determine how sensitive they are at detecting very small tumors and how specific they are in terms of distinguishing malignant tumors from benign tumors.
Official title: Novel Approaches to Molecular and Clinical Surveillance in Li-Fraumeni Syndrome - Pilot Study.
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2016-06-20
Completion Date
2025-12-31
Last Updated
2024-12-13
Healthy Volunteers
No
Conditions
Interventions
Whole body STIR MRI
Standard technique that detects abnormalities related to excess of water in tissues (edema).
DW-MRI
MRI technique that analyzes areas of dead cells within tissues, present in some types of tumor.
PET-MRI
MRI technique that detect's the cells' use of glucose, more intensely in harmful cells.
Locations (1)
The Hospital for Sick Children
Toronto, Ontario, Canada