Clinical Research Directory

Inclusion Criteria: * Patients aged from 18 to 70 years old. * Patients with a unifocal Glioblastoma (grade IV astrocytoma in the World Health Organization (WHO) classification) with postoperative macroscopic residue after biopsy or resection alone. * Location of the tumor or residual tumor, detected by Magnetic Resonance Imaging (MRI) sequences T1 gadolinium, more than 1cm from the optic chiasm * Diagnosis confirmed by pathology. * Time from surgery (if performed) and the start of radiation therapy less than 6 weeks. * performance status 0 or 1 in the WHO classification. * methylation status of the MGMT promoter gene requested * blood count: Neutrophil more than 1500/mm3 Platelets more than 100 000/mm3 * Liver function test Bilirubin less than 1,5 times upper limit transaminases than 3 times upper limit * patient informed and informed consent signed * Possibility to trat by radiation withintensity modulated (fixed beams modulated or rotational modulation (TomoTherapy, dynamic arctherapy)) strictly respecting the constraints to organs at risk (Crystalline: 8 Gy max, Posterior chamber of the eye: 45 Gy max , optic nerve: 54 Gy max, chiasm: 54 Gy max, brain Stem: 2% 58 Gy D2 \<64 Gy, Dmax \<69 Gy spinal cord: 46 Gy max, healthy brain (brain - PTV): 60 Gy max 33%, 50 Gy to 50% and D100 \<45 Gy to the brain in toto). * The patient must be affiliated to a social security scheme. Exclusion Criteria: * Other histological "Glioblastoma". * Excision macroscopically complete individualized on postoperative MRI. * Patient unable to give consent. * A patient with against-indication to performed MRI (pacemaker, uncontrollable claustrophobia ...). * The patient must not have received radiation therapy or previous chemotherapy for this condition. * Other neoplasia unstabilized and / or treated for less than 5 years. * Patient already included in another clinical trial with an experimental molecule. * Inability to submit to medical monitoring testing for geographical, social or psychological. * Pregnancy or breastfeeding * Private Person of liberty under supervision or under curatorship * No affiliation to a social security scheme or medical state aid or the universal medical coverage